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How to get fromPittsburgh to Lexingtonby bus (Greyhound), train (Amtrak), car, bus, plane, or train

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There are 8 ways to get from Pittsburgh to Lexington by bus (Greyhound), train (Amtrak), car, bus, plane, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus via Cambridge

    best
    1. Take the bus from Pittsburgh Intermodal Station to Cambridge, OHbus bus
    2. Take the bus from Cambridge to Charleston, WVbus bus
    3. Take the bus from Charleston Bus Station to Winston Salem(Trans Center)bus bus
    13h 3m
    $67–156

  2. Bus

    cheapest
    1. Take the bus from Pittsburgh Greyhound to Westover Terminalbus bus
    2. Take the bus from Morgantown to Charlestonbus bus
    3. Take the bus from Charleston Bus Station to Winston Salem(Trans Center)bus bus
    13h 38m
    $56–161

  3. Train (Amtrak)

    1. Take the train from Pittsburgh Amtrak Station to Carytrain train Floridian
    2. Take the train from Cary to High Pointtrain train Piedmont / ...
    18h 45m
    $224–459

  4. Drive 409.8 mi

    1. Drive from Pittsburgh to Lexingtoncar car 409.8 mi
    7h 18m
    $75–108

  5. Bus to Pittsburgh International Airport, fly to Piedmont Triad International Airport, line 3 bus, bus

    1. Take the bus from Seventh Ave + Smithfield St to Pittsburgh International Airportbus bus
    2. Fly from Pittsburgh International Airport (PIT) to Piedmont Triad International Airport (GSO)plane plane PIT - GSO
    3. Take the bus from Coble Transportation Center to High Point Terminalbus bus
    4. Take the bus from High Point Transportation Terminal to Lexington Davidson Co Trans Termbus bus
    8h 8m

  6. Bus to Pittsburgh International Airport, fly to Charlotte Douglas International Airport, train, bus

    1. Take the bus from Seventh Ave + Smithfield St to Pittsburgh International Airportbus bus
    2. Fly from Pittsburgh International Airport (PIT) to Charlotte Douglas International Airport (CLT)plane plane PIT - CLT
    3. Take the train from Charlotte Amtrak Station to High Pointtrain train
    4. Take the bus from High Point Transportation Terminal to Lexington Davidson Co Trans Termbus bus
    8h 32m

  7. Bus to Pittsburgh International Airport, fly to Raleigh-Durham International Airport, line 700 bus, train, bus

    1. Take the bus from Seventh Ave + Smithfield St to Pittsburgh International Airportbus bus
    2. Fly from Pittsburgh International Airport (PIT) to Raleigh-Durham International Airport (RDU)plane plane PIT - RDU
    3. Take the bus from Regional Transit Center to Durham Stationbus bus
    4. Take the train from Durham Amtrak Station to High Pointtrain train
    5. Take the bus from High Point Transportation Terminal to Lexington Davidson Co Trans Termbus bus
    8h 51m

  8. Drive to Altoona–Blair County Airport, fly to Charlotte Douglas International Airport, train

    1. Drive from Pittsburgh to Altoona–Blair County Airport (AOO)car car
    2. Fly from Altoona–Blair County Airport (AOO) to Charlotte Douglas International Airport (CLT)plane plane AOO - CLT
    3. Take the train from Charlotte Amtrak Station to High Pointtrain train
    8h 52m
    $208–302

Pittsburgh to Lexington by bus

Calendar7Weekly Buses
Duration13h 3mAverage Duration
Ticket$67Cheapest Price
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Questions & Answers

Map of how to get from Pittsburgh to Lexington.ExpandLaunch map view
  • Distance: 495.5 mi
  • Duration: 13h 3m

What companies run services between Pittsburgh, PA, USA and Lexington, NC, USA?

You can take a bus from Pittsburgh Intermodal Station to Lexington via Cambridge, OH, Cambridge, Charleston Bus Station, and Winston-Salem in around 13h 3m. Alternatively, you can take a train from Pittsburgh Amtrak Station to Lexington Davidson Co Trans Term via Cary, High Point, and High Point Transportation Terminal in around 18h 45m.

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