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How to get fromPittsburgh to Mayo Clinicby plane, train, bus, bus (Greyhound, Flixbus), car, or bus (Flixbus)

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There are 9 ways to get from Pittsburgh to Mayo Clinic by plane, train, bus, bus (Greyhound, Flixbus), car, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Pittsburgh International Airport to Rochester

    best
    1. Fly from Pittsburgh International Airport (PIT) to Rochester (RST)plane plane PIT - RST
    7h 49m
    $101–459

  2. Train, bus via Madison

    1. Take the train from Pittsburgh Amtrak Station to Chicago Union Stationtrain train
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    19h 30m
    $231–442

  3. Bus via Milwaukee

    1. Take the bus from Pittsburgh Intermodal Station to Chicago Bus Stationbus bus
    2. Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus bus
    3. Take the bus from Milwaukee to Rochesterbus bus
    19h 50m
    $162–275

  4. Drive 806.5 mi

    1. Drive from Pittsburgh to Mayo Cliniccar car 806.5 mi
    13h 19m
    $148–213

  5. Fly Pittsburgh International Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Pittsburgh International Airport (PIT) to Minneapolis–Saint Paul International Airport (MSP)plane plane PIT - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 15m
    $552–1,021

  6. Bus to Akron, fly to Rochester

    1. Take the bus from Pittsburgh Intermodal Station to Robert K Pfaff Transit Center - Akronbus bus
    2. Fly from Akron (CAK) to Rochester (RST)plane plane CAK - RST
    10h 32m
    $121–441

  7. Train to Cleveland-Hopkins International Airport, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the train from Pittsburgh Amtrak Station to Cleveland Amtraktrain train
    2. Fly from Cleveland-Hopkins International Airport (CLE) to Minneapolis–Saint Paul International Airport (MSP)plane plane CLE - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    9h 45m
    $650–1,145

  8. Train, bus

    1. Take the train from Pittsburgh Amtrak Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    3. Take the bus from St. Paul to Rochester, MNbus bus
    20h 55m
    $314–622

  9. Bus

    1. Take the bus from Pittsburgh Intermodal Station to Chicagobus bus
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    22h 3m
    $167–276

Pittsburgh to Mayo Clinic by train, bus, and foot

Calendar7Weekly Services
Duration20h 55mAverage Duration
Ticket$314Cheapest Price
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Questions & Answers

Map of how to get from Pittsburgh to Mayo Clinic.ExpandLaunch map view
  • Distance: 703.1 mi
  • Duration: 7h 49m

What companies run services between Pittsburgh, PA, USA and Mayo Clinic, MN, USA?

United Airlines, Delta, and American Airlines fly from Pittsburgh International Airport (PIT) to Rochester (RST) every 4 hours. Alternatively, you can take a bus from Pittsburgh Intermodal Station to Mayo Clinic via Chicago Bus Station, Milwaukee Intermodal Station, Milwaukee, and Rochester in around 19h 50m.

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