Rome2Rio

How to get fromPittsburgh to Mayo Clinicby plane, bus (Greyhound, Flixbus), train, bus, car, or bus (Flixbus)

Find Transport to Mayo Clinic

See all options

There are 9 ways to get from Pittsburgh to Mayo Clinic by plane, bus (Greyhound, Flixbus), train, bus, car, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Pittsburgh International Airport to Rochester

    best
    1. Fly from Pittsburgh International Airport (PIT) to Rochester (RST)plane plane PIT - RST
    7h 47m
    $92–527

  2. Bus to Akron, fly to Rochester

    cheapest
    1. Take the bus from Pittsburgh Intermodal Station to Robert K Pfaff Transit Center - Akronbus bus
    2. Fly from Akron (CAK) to Rochester (RST)plane plane CAK - RST
    12h 6m
    $87–451

  3. Bus via Milwaukee

    1. Take the bus from Pittsburgh Intermodal Station to Chicago Bus Stationbus bus
    2. Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus bus
    3. Take the bus from Milwaukee to Rochesterbus bus
    19h 26m
    $161–254

  4. Train, bus via Madison

    1. Take the train from Pittsburgh Amtrak Station to Chicago Union Stationtrain train
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    19h 30m
    $337–532

  5. Drive  806.4 mi

    1. Drive from Pittsburgh to Mayo Cliniccar car 806.4 mi
    13h 16m
    $138–200

  6. Fly Pittsburgh International Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Pittsburgh International Airport (PIT) to Minneapolis–Saint Paul International Airport (MSP)plane plane PIT - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 36m
    $171–688

  7. Train to Cleveland-Hopkins International Airport, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the train from Pittsburgh Amtrak Station to Cleveland Amtraktrain train
    2. Fly from Cleveland-Hopkins International Airport (CLE) to Minneapolis–Saint Paul International Airport (MSP)plane plane CLE - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    10h 7m
    $929–1,169

  8. Train, bus

    1. Take the train from Pittsburgh Amtrak Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    3. Take the bus from St. Paul to Rochesterbus bus
    20h 48m
    $510–792

  9. Bus

    1. Take the bus from Pittsburgh Intermodal Station to Chicagobus bus
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    22h 3m
    $167–263

Pittsburgh to Mayo Clinic by bus and foot

Calendar7Weekly Services
Duration19h 26mAverage Duration
Ticket$161Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Pittsburgh to Mayo Clinic.ExpandLaunch map view
  • Distance: 703.1 mi
  • Duration: 7h 47m

What companies run services between Pittsburgh, PA, USA and Mayo Clinic, MN, USA?

Delta and American Airlines fly from Pittsburgh International Airport (PIT) to Rochester (RST) 5 times a day. Alternatively, you can take a bus from Pittsburgh Intermodal Station to Mayo Clinic via Chicago Bus Station, Milwaukee Intermodal Station, Milwaukee, and Rochester in around 19h 26m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

Booking & Getting There