Rome2Rio

How to get fromPittsburgh to Middlesboroby plane, car, or bus

Find Transport to Middlesboro

See all options

There are 6 ways to get from Pittsburgh to Middlesboro by plane, car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Mcghee Tyson Airport, drive

    best
    1. Fly from Pittsburgh International Airport (PIT) to Mcghee Tyson Airport (TYS)plane plane PIT - TYS
    2. Drive from Mcghee Tyson Airport (TYS) to Middlesborocar car
    7h 26m
    $184–1,004

  2. Bus, drive via Columbus

    cheapest
    1. Take the bus from Pittsburgh Intermodal Station to Wilson & Ferrell Shell Station - Columbusbus bus
    2. Take the bus from N Wilson Rd & Ferrell Pl - Columbus to Cincinnati, OHbus bus
    3. Take the bus from Cincinnati Bus Station to Londonbus bus
    4. Drive from London to Middlesborocar car
    12h 26m
    $74–151

  3. Drive  451.8 mi

    1. Drive from Pittsburgh to Middlesborocar car 451.8 mi
    8h 33m
    $83–120

  4. Fly to Tri-Cities Regional Tn/Va Airport, drive

    1. Fly from Pittsburgh International Airport (PIT) to Tri-Cities Regional Tn/Va Airport (TRI)plane plane PIT - TRI
    2. Drive from Tri-Cities-Regional-Airport-TRI to Middlesborocar car
    8h 13m
    $91–463

  5. Bus, drive

    1. Take the bus from Pittsburgh Intermodal Station to Cincinnatibus bus
    2. Take the bus from Cincinnati Bus Station to Londonbus bus
    3. Drive from London to Middlesborocar car
    13h 26m
    $83–159

  6. Bus, drive #2

    1. Take the bus from Pittsburgh Intermodal Station to Dayton Trotwood Bus Stationbus bus
    2. Take the bus from Dayton Trotwood Bus Station to Londonbus bus
    3. Drive from London to Middlesborocar car
    13h 36m
    $78–133

Pittsburgh International Airport (PIT) to Mcghee Tyson Airport (TYS) flights

Calendar153Weekly Planes
Duration4h 40mAverage Duration
Ticket$170Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Pittsburgh to Middlesboro.ExpandLaunch map view
  • Distance: 481 mi
  • Duration: 7h 26m

What companies run services between Pittsburgh, PA, USA and Middlesboro, KY, USA?

There is no direct connection from Pittsburgh to Middlesboro. However, you can take the bus to Pittsburgh International Airport, walk to Pittsburgh-Airport-PIT airport, fly to Mcghee Tyson Airport (TYS), then drive to Middlesboro. Alternatively, you can take a bus from Pittsburgh Intermodal Station to Middlesboro via N Wilson Rd & Ferrell Pl - Columbus, Cincinnati, OH, Cincinnati Bus Station, and London in around 12h 26m.

Airlines
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound