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How to get fromPittsburgh to O'Fallonby plane, train, bus (Greyhound), train (Amtrak), or car

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There are 6 ways to get from Pittsburgh to O'Fallon by plane, train, bus (Greyhound), train (Amtrak), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Pittsburgh International Airport to Lambert–St. Louis International Airport, train

    best
    1. Fly from Pittsburgh International Airport (PIT) to Lambert–St. Louis International Airport (STL)plane plane PIT - STL
    2. Take the train from LAMBERT AIRPORT TERMINAL #1 station to SHILOH-SCOTT stationtrain train
    5h 58m
    $115–595

  2. Bus

    cheapest
    1. Take the bus from Pittsburgh Intermodal Station to St Louis Bus Stationbus bus Greyhound US0421
    14h 32m
    $100–185

  3. Train (Amtrak)

    1. Take the train from Pittsburgh Amtrak Station to Chicago Union Stationtrain train Floridian
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    17h 5m
    $249–505

  4. Drive 589.7 mi

    1. Drive from Pittsburgh to O'Falloncar car 589.7 mi
    10h 9m
    $108–156

  5. Train to Cleveland-Hopkins International Airport, fly to Lambert–St. Louis International Airport, train

    1. Take the train from Pittsburgh Amtrak Station to Cleveland Amtraktrain train
    2. Fly from Cleveland-Hopkins International Airport (CLE) to Lambert–St. Louis International Airport (STL)plane plane CLE - STL
    3. Take the train from LAMBERT AIRPORT TERMINAL #1 station to SHILOH-SCOTT stationtrain train
    8h 32m
    $542–997

  6. Fly Pittsburgh International Airport to Midamerica St. Louis Airport

    1. Fly from Pittsburgh International Airport (PIT) to Midamerica St. Louis Airport (BLV)plane plane PIT - BLV
    10h 20m
    $169–636

Pittsburgh to O'Fallon by bus and train

Calendar42Weekly Services
Duration14h 32mAverage Duration
Ticket$100Cheapest Price
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Questions & Answers

Map of how to get from Pittsburgh to O'Fallon.ExpandLaunch map view
  • Distance: 620 mi
  • Duration: 5h 58m

What companies run services between Pittsburgh, PA, USA and O'Fallon, IL, USA?

Greyhound USA operates a bus from Pittsburgh Intermodal Station to St Louis Bus Station 3 times a day. Tickets cost $95–190 and the journey takes 12h 55m. Greyhound-us also services this route 3 times a day. Alternatively, you can take a train from Pittsburgh Amtrak Station to Lincoln @ 3Rd Street Nb via Chicago Union Station, St. Louis, CIVIC CENTER station, SHILOH-SCOTT station, and Shiloh-Scott Transit Center in around 17h 5m.

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