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How to get fromPittsburgh to Saint Charlesby bus, plane, bus (Greyhound), train (Amtrak), car, or train

Find Transport to Saint Charles

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There are 5 ways to get from Pittsburgh to Saint Charles by bus, plane, bus (Greyhound), train (Amtrak), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Pittsburgh International Airport, fly

    best
    1. Take the bus from Seventh Ave + Smithfield St to Pittsburgh International Airportbus bus
    2. Fly from Pittsburgh International Airport (PIT) to Lambert–St. Louis International Airport (STL)plane plane PIT - STL
    5h 9m

  2. Drive  613.1 mi

    cheapest
    1. Drive from Pittsburgh to Saint Charlescar car 613.1 mi
    10h 26m
    $112–162

  3. Bus (Greyhound)

    1. Take the bus from Pittsburgh Intermodal Station to St Louis Bus Stationbus bus Greyhound US0421
    14h 29m
    $115–172

  4. Train (Amtrak)

    1. Take the train from Pittsburgh Amtrak Station to Chicago Union Stationtrain train Floridian
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    17h 6m
    $203–472

  5. Train to Cleveland-Hopkins International Airport, fly

    1. Take the train from Pittsburgh Amtrak Station to Cleveland Amtraktrain train
    2. Fly from Cleveland-Hopkins International Airport (CLE) to Lambert–St. Louis International Airport (STL)plane plane CLE - STL
    7h 43m
    $547–1,007

Pittsburgh International Airport (PIT) to Lambert–St. Louis International Airport (STL) flights

Calendar54Weekly Planes
Duration3h 12mAverage Duration
Ticket$107Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Pittsburgh to Saint Charles.ExpandLaunch map view
  • Distance: 596.2 mi
  • Duration: 5h 9m

What companies run services between Pittsburgh, PA, USA and Saint Charles, MO, USA?

Greyhound USA operates a bus from Pittsburgh Intermodal Station to St Louis Bus Station 3 times a day. Tickets cost $95–150 and the journey takes 12h 55m. Alternatively, you can take a train from Pittsburgh Amtrak Station to Saint Charles via Chicago Union Station, St. Louis, CIVIC CENTER station, NORTH HANLEY station, North Hanley Transit Center, and 4375 Rider Trail North Sb in around 17h 6m.

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