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How to get fromPittsburgh to Santeeby plane, car, bus (Greyhound), train, bus, or bus (Greyhound, Flixbus)

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There are 7 ways to get from Pittsburgh to Santee by plane, car, bus (Greyhound), train, bus, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Charleston International Airport, drive

    best
    1. Fly from Pittsburgh International Airport (PIT) to Charleston International Airport (CHS)plane plane PIT - CHS
    2. Drive from Charleston-Airport-CHS to Santeecar car
    5h
    $91–451

  2. Bus

    1. Take the bus from Pittsburgh Intermodal Station to Cambridge, OHbus bus
    2. Take the bus from Cambridge to Charleston, WVbus bus
    3. Take the bus from Charleston, WV to Charlotte Bus Stationbus bus
    4. Take the bus from Charlotte to Orangeburgbus bus
    15h 52m

  3. Train, drive (Amtrak)

    1. Take the train from Pittsburgh Amtrak Station to Petersburg Amtrak Stationtrain train
    2. Take the train from Petersburg Amtrak Station to Charleston Amtrak Stationtrain train
    3. Drive from Charleston Amtrak Station to Santeecar car
    19h 42m
    $260–536

  4. Drive 594.1 mi

    1. Drive from Pittsburgh to Santeecar car 594.1 mi
    10h 18m
    $109–157

  5. Fly to Columbia, drive

    1. Fly from Pittsburgh International Airport (PIT) to Columbia (CAE)plane plane PIT - CAE
    2. Drive from Columbia-Airport-CAE to Santeecar car
    6h 47m
    $178–951

  6. Fly to Savannah, bus

    1. Fly from Pittsburgh International Airport (PIT) to Savannah (SAV)plane plane PIT - SAV
    2. Take the bus from Savannah to Orangeburgbus bus
    7h 30m

  7. Bus via Washington

    1. Take the bus from Pittsburgh Intermodal Station to Washington Union Stationbus bus
    2. Take the bus from Washington Union Station to Raleigh Bus Stationbus bus
    3. Take the bus from Raleigh Bus Station to Orangeburgbus bus
    18h 7m
    $203–337

Pittsburgh International Airport (PIT) to Charleston International Airport (CHS) flights

Calendar60Weekly Planes
Duration3h 24mAverage Duration
Ticket$81Cheapest Price
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Questions & Answers

Map of how to get from Pittsburgh to Santee.ExpandLaunch map view
  • Distance: 610.7 mi
  • Duration: 5h

What companies run services between Pittsburgh, PA, USA and Santee, SC, USA?

You can take a bus from Pittsburgh Intermodal Station to Santee via Cambridge, OH, Cambridge, Charleston, WV, Charlotte, and Orangeburg in around 15h 52m.

Airlines
Train operators
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