There are 5 ways to get from Pittsburgh to Seneca by plane, taxi, train (Amtrak), bus, or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Greenville–Spartanburg International Airport, taxi
best- Fly from Pittsburgh International Airport (PIT) to Greenville–Spartanburg International Airport (GSP)plane PIT - GSP
- Take the taxi from Greenville–Spartanburg International Airport (GSP) to Senecataxi
4h 51m$232–773Fly to Asheville Regional Airport, drive
cheapest- Fly from Pittsburgh International Airport (PIT) to Asheville Regional Airport (AVL)plane PIT - AVL
- Drive from Asheville-Airport-AVL to Senecacar
7h 30m$82–431Train (Amtrak)
- Take the train from Pittsburgh Amtrak Station to Washington Union Stationtrain Floridian
- Take the train from Washington Union Station to Clemson Amtrak Stationtrain Crescent
20h 34m$232–511Bus, taxi
- Take the bus from Pittsburgh Intermodal Station to Columbusbus
- Take the bus from Columbus to Atlanta Bus Stationbus
- Take the bus from Atlanta to Flying J - Commercebus
- Take the taxi from Flying J - Commerce to Senecataxi
26h 45m$239–404Drive 541.4 mi
- Drive from Pittsburgh to Senecacar 541.4 mi
10h 17m$99–143
Pittsburgh International Airport (PIT) to Greenville–Spartanburg International Airport (GSP) flights
Questions & Answers
The cheapest way to get from Pittsburgh to Seneca is to drive which costs $95 - $150 and takes 10h 17m.
The fastest way to get from Pittsburgh to Seneca is to fly and taxi which takes 4h 51m and costs $230 - $800.
No, there is no direct train from Pittsburgh station to Seneca station. However, there are services departing from Pittsburgh Amtrak Station and arriving at Clemson Amtrak Station via Washington Union Station. The journey, including transfers, takes approximately 20h 34m.
The distance between Pittsburgh and Seneca is 479 miles. The road distance is 544.6 miles.
The best way to get from Pittsburgh to Seneca without a car is to train which takes 20h 34m and costs $230 - $550.
It takes approximately 4h 51m to get from Pittsburgh to Seneca, including transfers.
Pittsburgh to Seneca train services, operated by Amtrak, depart from Pittsburgh Amtrak Station.
Pittsburgh to Seneca train services, operated by Amtrak, arrive at Washington Union Station.
Yes, the driving distance between Pittsburgh to Seneca is 545 miles. It takes approximately 10h 17m to drive from Pittsburgh to Seneca.
Book your Pittsburgh to Seneca train tickets online with Omio.
What companies run services between Pittsburgh, PA, USA and Seneca, SC, USA?
You can take a train from Pittsburgh Amtrak Station to Seneca via Washington Union Station and Clemson Amtrak Station in around 20h 34m.
- Website
- aa.com
Flights from Pittsburgh International Airport to Greenville–Spartanburg International Airport via Charlotte
- Ave. Duration
- 3h 36m
- When
- Thursday and Tuesday
- Estimated price
- $100–650
Flights from Pittsburgh International Airport to Asheville Regional Airport via Charlotte
- Ave. Duration
- 3h 58m
- When
- Every day
- Estimated price
- $70–420
Flights from Pittsburgh International Airport to Asheville Regional Airport via Reagan Washington
- Ave. Duration
- 4h 20m
- When
- Every day
- Estimated price
- $80–450
Flights from Pittsburgh International Airport to Asheville Regional Airport via Philadelphia
- Ave. Duration
- 5h 49m
- When
- Every day
- Estimated price
- $95–490
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Pittsburgh Amtrak Station to Washington Union Station
- Ave. Duration
- 7h 45m
- Frequency
- Once daily
- Estimated price
- $75–180
- Website
- Amtrak
Train from Washington Union Station to Clemson Amtrak Station
- Ave. Duration
- 11h 37m
- Frequency
- Once daily
- Estimated price
- $130–310
- Website
- Amtrak
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Pittsburgh Intermodal Station to Columbus
- Ave. Duration
- 3h 10m
- Frequency
- 3 times a day
- Estimated price
- $25–50
- Website
- Greyhound
Bus from Columbus to Atlanta Bus Station
- Ave. Duration
- 17h 55m
- Frequency
- Once daily
- Estimated price
- $90–180
- Website
- Greyhound
- Ave. Duration
- 56 min
- Estimated price
- $100–170
GVL Taxi
- Phone
- +1 864-920-3352
- Website
- gvltaxi.com
Personal Touch Transportation
- Phone
- +18645250420
Yellow Cab Greenville
- Phone
- +1 864-233-6666
- Website
- yellowcabgreenville.com
Checker Cab
- Phone
- +1 864-583-2721
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Why you should take the train in the US
Read the travel guide
Need to know: Greyhound
Read the travel guide
More Questions & Answers
There are 171+ hotels available in Seneca.





