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How to get fromPittsburgh to University of Chicagoby bus, plane, train (Amtrak), bus (Greyhound, Amtrak), car, train, or bus (Flixbus)

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There are 8 ways to get from Pittsburgh to University of Chicago by bus, plane, train (Amtrak), bus (Greyhound, Amtrak), car, train, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Pittsburgh International Airport, fly to Chicago Midway International Airport

    best
    1. Take the bus from Seventh Ave + Smithfield St to Pittsburgh International Airportbus bus
    2. Fly from Pittsburgh International Airport (PIT) to Chicago Midway International Airport (MDW)plane plane PIT - MDW
    4h 41m

  2. Drive 453.4 mi

    cheapest
    1. Drive from Pittsburgh to University of Chicagocar car 453.4 mi
    7h 28m
    $83–120

  3. Train (Amtrak)

    1. Take the train from Pittsburgh Amtrak Station to Chicago Union Stationtrain train Floridian
    10h 55m
    $155–318

  4. Bus via Toledo

    1. Take the bus from Pittsburgh Intermodal Station to Toledo Bus Stopbus bus Greyhound US0164 / ...
    2. Take the bus from Toledo to Chicago Union Stationbus bus Amtrak Thruway Connecting Service
    11h 1m
    $121–193

  5. Bus to Pittsburgh International Airport, fly to Chicago O'Hare International Airport, train

    1. Take the bus from Seventh Ave + Smithfield St to Pittsburgh International Airportbus bus
    2. Fly from Pittsburgh International Airport (PIT) to Chicago O'Hare International Airport (ORD)plane plane PIT - ORD
    3. Take the train from Van Buren St. to 55th - 56th - 57th St.train train
    5h 31m

  6. Train to Cleveland-Hopkins International Airport, fly to Chicago Midway International Airport

    1. Take the train from Pittsburgh Amtrak Station to Cleveland Amtraktrain train
    2. Fly from Cleveland-Hopkins International Airport (CLE) to Chicago Midway International Airport (MDW)plane plane CLE - MDW
    7h 10m
    $104–476

  7. Train to Johnstown-Cambria County Airport, fly to Chicago O'Hare International Airport

    1. Take the train from Pittsburgh Amtrak Station to Johnstown Amtrak Stationtrain train
    2. Fly from Johnstown-Cambria County Airport (JST) to Chicago O'Hare International Airport (ORD)plane plane JST - ORD
    6h 18m
    $88–368

  8. Bus (Flixbus)

    1. Take the bus from Pittsburgh Intermodal Station to Chicagobus bus FlixBus N2640
    11h 49m
    $86–137

Pittsburgh to University of Chicago by train, bus, and foot (Amtrak)

Calendar7Weekly Services
Duration10h 55mAverage Duration
Ticket$155Cheapest Price
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Questions & Answers

Map of how to get from Pittsburgh to University of Chicago.ExpandLaunch map view
  • Distance: 447.8 mi
  • Duration: 4h 41m

What companies run services between Pittsburgh, PA, USA and University of Chicago, IL, USA?

Amtrak operates a train from Pittsburgh Amtrak Station to Chicago Union Station once daily. Tickets cost $140–320 and the journey takes 9h 46m. Alternatively, you can take a bus from Pittsburgh Intermodal Station to University of Chicago via Toledo, Chicago Union Station, Jackson & Clinton, Congress Plaza & Michigan, Balbo & Michigan, and Cottage Grove & 59th Street in around 11h 1m.

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