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How to get fromPittsburgh to Wiseby bus, car, train, or plane

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There are 8 ways to get from Pittsburgh to Wise by bus, car, train, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, drive via Cambridge

    best
    1. Take the bus from Pittsburgh Intermodal Station to Cambridge, OHbus bus
    2. Take the bus from Cambridge to Charleston, WVbus bus
    3. Take the bus from Charleston, WV to Wythevillebus bus
    4. Take the bus from Wytheville Rural King Parking Lot to Bristol Exit 5 Park & Ride Lotbus bus
    5. Drive from Bristol Exit 5 Park & Ride Lot to Wisecar car
    12h 54m
    $93–189

  2. Drive  379.5 mi

    cheapest
    1. Drive from Pittsburgh to Wisecar car 379.5 mi
    7h 4m
    $70–100

  3. Train, bus, drive via Roanoke

    1. Take the train from Pittsburgh Amtrak Station to Washington Union Stationtrain train
    2. Take the train from Washington Union Station to Roanoketrain train
    3. Take the bus from Roanoke Amtrak Station to Exit 118 - Park and Ridebus bus Swb
    4. Take the bus from Christiansburg to Bristol Exit 5 Park & Ride Lotbus bus
    5. Drive from Bristol Exit 5 Park & Ride Lot to Wisecar car
    20h 31m
    $157–346

  4. Fly to Tri-Cities Regional Tn/Va Airport, drive

    1. Fly from Pittsburgh International Airport (PIT) to Tri-Cities Regional Tn/Va Airport (TRI)plane plane PIT - TRI
    2. Drive from Tri-Cities-Regional-Airport-TRI to Wisecar car
    7h 58m
    $84–452

  5. Bus, drive

    1. Take the bus from Pittsburgh Greyhound to Westover Terminalbus bus
    2. Take the bus from Morgantown to Charlestonbus bus
    3. Take the bus from Charleston, WV to Wythevillebus bus
    4. Take the bus from Wytheville Rural King Parking Lot to Bristol Exit 5 Park & Ride Lotbus bus
    5. Drive from Bristol Exit 5 Park & Ride Lot to Wisecar car
    13h 29m
    $81–198

  6. Bus, drive via Washington

    1. Take the bus from Pittsburgh Intermodal Station to Washington Union Stationbus bus
    2. Take the bus from Washington Union Station to Bristol Exit 5 Park & Ride Lotbus bus
    3. Drive from Bristol Exit 5 Park & Ride Lot to Wisecar car
    15h 31m
    $96–139

  7. Train, bus, drive

    1. Take the train from Pittsburgh Amtrak Station to Washington Union Stationtrain train
    2. Take the bus from Washington Union Station to Bristol Exit 5 Park & Ride Lotbus bus
    3. Drive from Bristol Exit 5 Park & Ride Lot to Wisecar car
    18h 11m
    $131–247

  8. Fly to Greenville–Spartanburg International Airport, drive

    1. Fly from Pittsburgh International Airport (PIT) to Greenville–Spartanburg International Airport (GSP)plane plane PIT - GSP
    2. Drive from Greenville–Spartanburg International Airport (GSP) to Wisecar car
    8h 1m
    $154–754

Pittsburgh International Airport (PIT) to Tri-Cities Regional Tn/Va Airport (TRI) flights

Calendar83Weekly Planes
Duration5h 15mAverage Duration
Ticket$73Cheapest Price
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Comparing Your Travel Options

Map of how to get from Pittsburgh to Wise.ExpandLaunch map view
  • Distance: 507.5 mi
  • Duration: 12h 54m

What companies run services between Pittsburgh, PA, USA and Wise, VA, USA?

There is no direct connection from Pittsburgh to Wise. However, you can take the bus to Cambridge, OH, walk to Cambridge, take the bus to Charleston, WV, take the bus to Wytheville, take the taxi to Wytheville Rural King Parking Lot, take the bus to Bristol Exit 5 Park & Ride Lot, then drive to Wise. Alternatively, you can take a train from Pittsburgh Amtrak Station to Wise via Washington Union Station, Roanoke, Roanoke Amtrak Station, Exit 118 - Park and Ride, Christiansburg, and Bristol Exit 5 Park & Ride Lot in around 20h 31m.

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