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How to get fromPlymouth to Chicagoby bus, plane, train (Amtrak), bus (Greyhound, Flixbus), car, or train

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There are 8 ways to get from Plymouth to Chicago by bus, plane, train (Amtrak), bus (Greyhound, Flixbus), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, fly to Chicago Midway International Airport

    best
    1. Take the bus from Comfort Inn - Plymouth to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Chicago Midway International Airport (MDW)plane plane MSP - MDW
    3h 40m
    $57–365

  2. Train (Amtrak)

    1. Take the train from St. Paul-Minneapolis to Chicago Union Stationtrain train Borealis / ...
    9h 45m
    $132–273

  3. Bus

    1. Take the bus from Saint Paul Union Depot to Chicago Bus Stationbus bus Greyhound US0150
    10h 10m
    $62–123

  4. Drive 419.7 mi

    1. Drive from Plymouth to Chicagocar car 419.7 mi
    6h 54m
    $77–111

  5. Bus, fly to Chicago O'Hare International Airport

    1. Take the bus from Comfort Inn - Plymouth to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Chicago O'Hare International Airport (ORD)plane plane MSP - ORD
    3h 51m
    $222–455

  6. Fly to South Bend, train

    1. Fly from Minneapolis–Saint Paul International Airport (MSP) to South Bend (SBN)plane plane MSP - SBN
    2. Take the train from South Bend Airport to Van Buren St.train train
    6h 5m
    $108–615

  7. Fly to General Mitchell International Airport, train

    1. Fly from Minneapolis–Saint Paul International Airport (MSP) to General Mitchell International Airport (MKE)plane plane MSP - MKE
    2. Take the train from Milwaukee to Chicago Union Stationtrain train
    5h 49m
    $629–1,074

  8. Bus via Madison

    1. Take the bus from Minneapolis to Madisonbus bus Jefferson Lines 965
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus Van Galder
    13h 6m
    $88–162

Plymouth to Chicago by bus and foot

Calendar9Weekly Services
Duration13h 6mAverage Duration
Ticket$88Cheapest Price
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Questions & Answers

Map of how to get from Plymouth to Chicago.ExpandLaunch map view
  • Distance: 380.5 mi
  • Duration: 3h 40m

What companies run services between Plymouth, MN, USA and Chicago, IL, USA?

Amtrak operates a train from St. Paul-Minneapolis to Chicago Union Station 3 times a day. Tickets cost $130–270 and the journey takes 7h 32m. Alternatively, Greyhound USA operates a bus from Saint Paul Union Depot to Chicago Bus Station every 4 hours. Tickets cost $60–120 and the journey takes 7h 55m. Flixbus USA also services this route twice daily.

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