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How to get fromPoplar Bluff to Mayo Clinicby car, bus, train, or plane

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There are 8 ways to get from Poplar Bluff to Mayo Clinic by car, bus, train, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive, bus

    best
    1. Drive from Poplar Bluff to Flying J - Matthewscar car
    2. Take the bus from Flying J - Matthews to Water & Chicago - Circle Kbus bus
    3. Take the bus from Milwaukee to Rochesterbus bus
    17h 5m
    $180–234

  2. Drive to Barkley Regional Airport, fly to Rochester

    cheapest
    1. Drive from Poplar Bluff to Barkley Regional Airport (PAH)car car
    2. Fly from Barkley Regional Airport (PAH) to Rochester (RST)plane plane PAH - RST
    9h 52m
    $84–446

  3. Train, bus via Madison

    1. Take the train from Poplar Bluff Station to Chicago Union Stationtrain train
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    20h 44m
    $320–505

  4. Drive  585.7 mi

    1. Drive from Poplar Bluff to Mayo Cliniccar car 585.7 mi
    10h 59m
    $104–150

  5. Train to Lambert–St. Louis International Airport, fly to Rochester

    1. Take the train from Poplar Bluff Station to St. Louistrain train
    2. Fly from Lambert–St. Louis International Airport (STL) to Rochester (RST)plane plane STL - RST
    12h 1m
    $164–611

  6. Train, bus

    1. Take the train from Poplar Bluff Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    3. Take the bus from St. Paul to Rochesterbus bus
    22h 2m
    $493–765

  7. Train to Lambert–St. Louis International Airport, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the train from Poplar Bluff Station to St. Louistrain train
    2. Fly from Lambert–St. Louis International Airport (STL) to Minneapolis–Saint Paul International Airport (MSP)plane plane STL - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    11h 9m
    $228–741

  8. Drive to Cape Girardeau Municipal Airport, fly to Rochester

    1. Drive from Poplar Bluff to Cape Girardeau Municipal Airport (CGI)car car
    2. Fly from Cape Girardeau Municipal Airport (CGI) to Rochester (RST)plane plane CGI - RST
    9h 4m
    $123–608

Poplar Bluff to Mayo Clinic by train, bus, and foot

Calendar7Weekly Services
Duration20h 44mAverage Duration
Ticket$320Cheapest Price
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Comparing Your Travel Options

Map of how to get from Poplar Bluff to Mayo Clinic.ExpandLaunch map view
  • Distance: 825.6 mi
  • Duration: 17h 5m

What companies run services between Poplar Bluff, MO, USA and Mayo Clinic, MN, USA?

There is no direct connection from Poplar Bluff to Mayo Clinic. However, you can drive to Flying J - Matthews, take the bus to Water & Chicago - Circle K, walk to Milwaukee, take the bus to Rochester, then walk to Mayo Clinic. Alternatively, you can take a train from Poplar Bluff Station to Mayo Clinic via Chicago Union Station, W Jackson Blvd, after S Clinton St, 250 N. Lake St - Madison UW Campus, Madison, and Rochester in around 20h 44m.

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