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How to get fromPoplar Bluff to Mayo Clinicby car, plane, bus, or train

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There are 9 ways to get from Poplar Bluff to Mayo Clinic by car, plane, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Barkley Regional Airport, fly to Rochester

    best
    1. Drive from Poplar Bluff to Barkley Regional Airport (PAH)car car
    2. Fly from Barkley Regional Airport (PAH) to Rochester (RST)plane plane PAH - RST
    8h 9m
    $84–387

  2. Drive, bus

    1. Drive from Poplar Bluff to Flying J - Matthewscar car
    2. Take the bus from Flying J - Matthews to Water & Chicago - Circle Kbus bus
    3. Take the bus from Milwaukee to Rochesterbus bus
    17h 6m
    $170–324

  3. Train, bus via Chicago

    1. Take the train from Poplar Bluff Station to Chicago Union Stationtrain train
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    20h 44m
    $220–420

  4. Drive 585.6 mi

    1. Drive from Poplar Bluff to Mayo Cliniccar car 585.6 mi
    11h 3m
    $107–155

  5. Train to Lambert–St. Louis International Airport, fly to Rochester

    1. Take the train from Poplar Bluff Station to St. Louistrain train
    2. Fly from Lambert–St. Louis International Airport (STL) to Rochester (RST)plane plane STL - RST
    11h 40m
    $136–560

  6. Train to Lambert–St. Louis International Airport, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the train from Poplar Bluff Station to St. Louistrain train
    2. Fly from Lambert–St. Louis International Airport (STL) to Minneapolis–Saint Paul International Airport (MSP)plane plane STL - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    10h 47m
    $488–1,112

  7. Drive to Cape Girardeau Municipal Airport, fly to Rochester

    1. Drive from Poplar Bluff to Cape Girardeau Municipal Airport (CGI)car car
    2. Fly from Cape Girardeau Municipal Airport (CGI) to Rochester (RST)plane plane CGI - RST
    9h 9m
    $173–668

  8. Train, bus

    1. Take the train from Poplar Bluff Station to St. Louistrain train
    2. Take the bus from St Louis Bus Station to Des Moinesbus bus
    3. Take the bus from Des Moines to Albert Leabus bus
    4. Take the bus from Albert Lea to Rochesterbus bus
    20h 49m

  9. Train, bus #2

    1. Take the train from Poplar Bluff Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    3. Take the bus from St. Paul to Rochester, MNbus bus
    22h 9m
    $303–600

Poplar Bluff to Mayo Clinic by train, bus, and foot

Calendar10Weekly Services
Duration22h 9mAverage Duration
Ticket$303Cheapest Price
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Questions & Answers

Map of how to get from Poplar Bluff to Mayo Clinic.ExpandLaunch map view
  • Distance: 622.9 mi
  • Duration: 8h 9m

What companies run services between Poplar Bluff, MO, USA and Mayo Clinic, MN, USA?

There is no direct connection from Poplar Bluff to Mayo Clinic. However, you can drive to Barkley Regional Airport (PAH) airport, fly to Rochester (RST), walk to Rochester, take the bus to Rochester, then walk to Mayo Clinic. Alternatively, you can take a vehicle from Poplar Bluff to Mayo Clinic via Flying J - Matthews, Water & Chicago - Circle K, Milwaukee, and Rochester in around 17h 6m.

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