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How to get fromPort Saint Lucie to Buffaloby bus, plane, bus (Greyhound), train, or car

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There are 7 ways to get from Port Saint Lucie to Buffalo by bus, plane, bus (Greyhound), train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Orlando, fly to Buffalo Niagara International Airport

    best
    1. Take the bus from Fort Pierce to Orlando RedCoach Stationbus bus
    2. Fly from Orlando (MCO) to Buffalo Niagara International Airport (BUF)plane plane MCO - BUF
    6h 37m
    $171–383

  2. Bus

    1. Take the bus from Fort Pierce to Orlando RedCoach Stationbus bus
    2. Take the bus from Orlando RedCoach Station to Atlanta - Civic Center MARTA Stationbus bus
    3. Take the bus from Atlanta Bus Station to Cleveland Bus Stationbus bus
    4. Take the bus from Cleveland Bus Station to Buffalobus bus
    34h 4m
    $301–575

  3. Bus, train via New York

    1. Take the bus from Fort Pierce to Kissimmee -1471 East Osceola Parkwaybus bus
    2. Take the train from Kissimmee Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the train from Ny Moynihan Train Hall At Penn Station to Buffalotrain train
    36h 23m
    $538–1,090

  4. Drive 1,266 mi

    1. Drive from Port Saint Lucie to Buffalocar car 1,266 mi
    21h 19m
    $231–334

  5. Bus to Fort Lauderdale–Hollywood International Airport, fly to Buffalo Niagara International Airport

    1. Take the bus from Fort Pierce to Fort Lauderdale Airportbus bus
    2. Fly from Fort Lauderdale–Hollywood International Airport (FLL) to Buffalo Niagara International Airport (BUF)plane plane FLL - BUF
    6h 39m
    $194–871

  6. Bus to Orlando, fly to Rochester, bus

    1. Take the bus from Fort Pierce to Orlando RedCoach Stationbus bus
    2. Fly from Orlando (MCO) to Rochester (ROC)plane plane MCO - ROC
    3. Take the bus from Rochester Bus Stop to Buffalobus bus
    7h 41m
    $289–648

  7. Bus, train

    1. Take the bus from Fort Pierce to Kissimmee -1471 East Osceola Parkwaybus bus
    2. Take the train from Kissimmee Amtrak Station to Pittsburgh Amtrak Stationtrain train
    3. Take the bus from Pittsburgh, Pa to Buffalo, Nybus bus 510
    42h 15m
    $473–1,090

Port Saint Lucie to Buffalo by bus and subway

Calendar7Weekly Services
Duration34h 4mAverage Duration
Ticket$301Cheapest Price
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Questions & Answers

Map of how to get from Port Saint Lucie to Buffalo.ExpandLaunch map view
  • Distance: 1,155.9 mi
  • Duration: 6h 37m

What companies run services between Port Saint Lucie, FL, USA and Buffalo, NY, USA?

You can take a bus from Fort Pierce to Buffalo via Orlando RedCoach Station, Atlanta - Civic Center MARTA Station, Civic Center Station, Garnett Station, Atlanta Bus Station, and Cleveland Bus Station in around 34h 4m.

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