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How to get fromPort Saint Lucie to Charlestonby bus, plane, train, or car

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There are 8 ways to get from Port Saint Lucie to Charleston by bus, plane, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to President Donald J. Trump International Airport, fly

    best
    1. Take the bus from GATLIN BLVD at I-95 P/R LOT to WPB ITC at BAY Dbus bus
    2. Fly from President Donald J. Trump International Airport (PBI) to Charleston International Airport (CHS)plane plane PBI - CHS
    6h 27m
    $152–806

  2. Drive 471 mi

    cheapest
    1. Drive from Port Saint Lucie to Charlestoncar car 471 mi
    8h 2m
    $86–125

  3. Bus, train

    1. Take the bus from GATLIN BLVD at I-95 P/R LOT to WPB ITC at TRI RAILbus bus 95
    2. Take the train from West Palm Beach Amtrak Station to Charleston Amtrak Stationtrain train Silver Meteor
    14h 2m
    $253–479

  4. Bus to Fort Lauderdale–Hollywood International Airport, fly

    1. Take the bus from Fort Pierce to Sheridan Tri-Rail Stationbus bus
    2. Fly from Fort Lauderdale–Hollywood International Airport (FLL) to Charleston International Airport (CHS)plane plane FLL - CHS
    6h 42m
    $203–1,145

  5. Bus to Miami International Airport, fly

    1. Take the bus from Fort Pierce to Sheridan Tri-Rail Stationbus bus
    2. Fly from Miami International Airport (MIA) to Charleston International Airport (CHS)plane plane MIA - CHS
    7h 9m
    $535–1,046

  6. Bus to Orlando, fly

    1. Take the bus from Fort Pierce to Kissimmee -1471 East Osceola Parkwaybus bus
    2. Fly from Orlando (MCO) to Charleston International Airport (CHS)plane plane MCO - CHS
    7h 17m
    $101–295

  7. Bus to Tampa, fly

    1. Take the bus from Port St Lucie to Tampa Bus Stationbus bus
    2. Fly from Tampa (TPA) to Charleston International Airport (CHS)plane plane TPA - CHS
    9h 37m
    $205–436

  8. Bus, train via Buenaventura Lakes

    1. Take the bus from Fort Pierce to Kissimmee -1471 East Osceola Parkwaybus bus Miami to Orlando
    2. Take the train from Kissimmee Amtrak Station to Charleston Amtrak Stationtrain train Silver Meteor
    14h 12m
    $166–325

Port Saint Lucie to Charleston by bus and train

Calendar7Weekly Services
Duration14h 12mAverage Duration
Ticket$166Cheapest Price
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Questions & Answers

Map of how to get from Port Saint Lucie to Charleston.ExpandLaunch map view
  • Distance: 505 mi
  • Duration: 6h 27m

What companies run services between Port Saint Lucie, FL, USA and Charleston, SC, USA?

There is no direct connection from Port Saint Lucie to Charleston. However, you can take the taxi to GATLIN BLVD at I-95 P/R LOT, take the bus to WPB ITC at BAY D, walk to WPB ITC at BAY L, take the line 44 bus to TURNAGE BLVD at PBI TRM, walk to President Donald J. Trump International Airport (PBI) airport, fly to Charleston International Airport (CHS), walk to Charleston International Airport, then take the line 11 bus to Transit Mall. Alternatively, you can take a vehicle from Port Saint Lucie to Charleston via GATLIN BLVD at I-95 P/R LOT, WPB ITC at TRI RAIL, West Palm Beach Amtrak Station, and Charleston Amtrak Station in around 14h 2m.

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