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How to get fromPort Saint Lucie to Cherokeeby car, plane, bus, taxi, or train

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There are 9 ways to get from Port Saint Lucie to Cherokee by car, plane, bus, taxi, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Orlando Sanford, fly to Asheville Regional Airport, drive

    best
    1. Drive from Port Saint Lucie to Orlando-Sanford-Airport-SFBcar car
    2. Fly from Orlando Sanford (SFB) to Asheville Regional Airport (AVL)plane plane SFB - AVL
    3. Drive from Asheville-Airport-AVL to Cherokeecar car
    5h 25m
    $89–400

  2. Bus, taxi

    1. Take the bus from Fort Pierce to Orlandobus bus
    2. Take the bus from Orlando Bus Station to Raleigh Bus Stationbus bus
    3. Take the bus from Raleigh Bus Station to Asheville, NCbus bus
    4. Take the taxi from Asheville, NC to Cherokeetaxi taxi
    23h 7m
    $303–447

  3. Bus, train, taxi

    1. Take the bus from Fort Pierce to Kissimmee -1471 East Osceola Parkwaybus bus
    2. Take the train from Kissimmee Amtrak Station to Carytrain train
    3. Take the train from Cary to Greensborotrain train
    4. Take the bus from Greensboro Bus Stop to Asheville, NCbus bus
    5. Take the taxi from Asheville, NC to Cherokeetaxi taxi
    26h
    $419–741

  4. Drive 654.1 mi

    1. Drive from Port Saint Lucie to Cherokeecar car 654.1 mi
    13h 11m
    $120–173

  5. Bus to President Donald J. Trump International Airport, fly to Asheville Regional Airport, drive

    1. Take the bus from GATLIN BLVD at I-95 P/R LOT to WPB ITC at TRI RAILbus bus
    2. Fly from President Donald J. Trump International Airport (PBI) to Asheville Regional Airport (AVL)plane plane PBI - AVL
    3. Drive from Asheville-Airport-AVL to Cherokeecar car
    6h 26m
    $125–496

  6. Drive to Orlando Sanford, fly to Mcghee Tyson Airport, drive

    1. Drive from Port Saint Lucie to Orlando-Sanford-Airport-SFBcar car
    2. Fly from Orlando Sanford (SFB) to Mcghee Tyson Airport (TYS)plane plane SFB - TYS
    3. Drive from Mcghee Tyson Airport (TYS) to Cherokeecar car
    6h 12m
    $157–754

  7. Bus to Fort Lauderdale–Hollywood International Airport, fly to Asheville Regional Airport, drive

    1. Take the bus from Fort Pierce to Sheridan Tri-Rail Stationbus bus
    2. Fly from Fort Lauderdale–Hollywood International Airport (FLL) to Asheville Regional Airport (AVL)plane plane FLL - AVL
    3. Drive from Asheville-Airport-AVL to Cherokeecar car
    6h 44m
    $111–448

  8. Bus to Orlando, fly to Mcghee Tyson Airport, drive

    1. Take the bus from Fort Pierce to Kissimmee -1471 East Osceola Parkwaybus bus
    2. Fly from Orlando (MCO) to Mcghee Tyson Airport (TYS)plane plane MCO - TYS
    3. Drive from Mcghee Tyson Airport (TYS) to Cherokeecar car
    7h 58m
    $157–712

  9. Bus to Fort Lauderdale–Hollywood International Airport, fly to Mcghee Tyson Airport, drive

    1. Take the bus from Fort Pierce to Sheridan Tri-Rail Stationbus bus
    2. Fly from Fort Lauderdale–Hollywood International Airport (FLL) to Mcghee Tyson Airport (TYS)plane plane FLL - TYS
    3. Drive from Mcghee Tyson Airport (TYS) to Cherokeecar car
    7h 34m
    $184–862

Orlando Sanford (SFB) to Asheville Regional Airport (AVL) flights

Calendar11Weekly Planes
Duration1h 39mAverage Duration
Ticket$58Cheapest Price
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Questions & Answers

Map of how to get from Port Saint Lucie to Cherokee.ExpandLaunch map view
  • Distance: 654.2 mi
  • Duration: 5h 25m

What companies run services between Port Saint Lucie, FL, USA and Cherokee, NC, USA?

There is no direct connection from Port Saint Lucie to Cherokee. However, you can drive to Orlando-Sanford-Airport-SFB airport, fly to Asheville Regional Airport (AVL), then drive to Cherokee. Alternatively, you can take the bus to Orlando, take the line 36 bus to N Garland Ave & W Amelia St, take the line 25 bus to N John Young Pkwy & Business Center Blvd, walk to Orlando Bus Station, take the bus to Raleigh Bus Station, take the bus to Asheville, NC, then take the taxi to Cherokee.

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