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How to get fromPort Saint Lucie to Chicagoby bus, plane, bus (Flixbus, Greyhound), train, or car

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There are 8 ways to get from Port Saint Lucie to Chicago by bus, plane, bus (Flixbus, Greyhound), train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Orlando, fly to Chicago Midway International Airport

    best
    1. Take the bus from Fort Pierce to Kissimmee -1471 East Osceola Parkwaybus bus
    2. Fly from Orlando (MCO) to Chicago Midway International Airport (MDW)plane plane MCO - MDW
    7h 47m
    $216–458

  2. Bus to Orlando, fly to Chicago O'Hare International Airport

    cheapest
    1. Take the bus from Fort Pierce to Kissimmee -1471 East Osceola Parkwaybus bus
    2. Fly from Orlando (MCO) to Chicago O'Hare International Airport (ORD)plane plane MCO - ORD
    8h 10m
    $106–448

  3. Bus

    1. Take the bus from Port St Lucie to Atlanta Bus Stationbus bus FlixBus N2401
    2. Take the bus from Atlanta Bus Station to Chicago Bus Stationbus bus Greyhound US0100
    27h 20m
    $226–356

  4. Bus, train

    1. Take the bus from Fort Pierce to Kissimmee -1471 East Osceola Parkwaybus bus Miami to Orlando
    2. Take the train from Kissimmee Amtrak Station to Chicago Union Stationtrain train Floridian
    43h 31m
    $982–1,541

  5. Drive  1,220.8 mi

    1. Drive from Port Saint Lucie to Chicagocar car 1,220.8 mi
    21h 28m
    $223–322

  6. Bus to Fort Lauderdale–Hollywood International Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from Fort Pierce to Sheridan Tri-Rail Stationbus bus
    2. Fly from Fort Lauderdale–Hollywood International Airport (FLL) to Chicago O'Hare International Airport (ORD)plane plane FLL - ORD
    7h 29m
    $193–458

  7. Bus to Fort Lauderdale–Hollywood International Airport, fly to Chicago Midway International Airport

    1. Take the bus from Fort Pierce to Sheridan Tri-Rail Stationbus bus
    2. Fly from Fort Lauderdale–Hollywood International Airport (FLL) to Chicago Midway International Airport (MDW)plane plane FLL - MDW
    7h 14m
    $183–418

  8. Bus to Orlando, fly to General Mitchell International Airport, train

    1. Take the bus from Fort Pierce to Kissimmee -1471 East Osceola Parkwaybus bus
    2. Fly from Orlando (MCO) to General Mitchell International Airport (MKE)plane plane MCO - MKE
    3. Take the train from Milwaukee to Chicago Union Stationtrain train
    10h 7m
    $491–1,232

Port Saint Lucie to Chicago by bus and train

Calendar7Weekly Services
Duration43h 31mAverage Duration
Ticket$982Cheapest Price
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Comparing Your Travel Options

Map of how to get from Port Saint Lucie to Chicago.ExpandLaunch map view
  • Distance: 1,137.3 mi
  • Duration: 7h 47m

What companies run services between Port Saint Lucie, FL, USA and Chicago, IL, USA?

You can take a vehicle from Port Saint Lucie to Chicago Bus Station via Port St Lucie and Atlanta Bus Station in around 27h 20m.

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