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How to get fromPort Saint Lucie to Destinby bus, plane, taxi, or car

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There are 10 ways to get from Port Saint Lucie to Destin by bus, plane, taxi, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Miami International Airport, fly to Destin–Fort Walton Beach Airport

    best
    1. Take the bus from Fort Pierce to Sheridan Tri-Rail Stationbus bus
    2. Fly from Miami International Airport (MIA) to Destin–Fort Walton Beach Airport (VPS)plane plane MIA - VPS
    6h 11m
    $123–409

  2. Drive  498.3 mi

    cheapest
    1. Drive from Port Saint Lucie to Destincar car 498.3 mi
    9h 10m
    $89–128

  3. Bus, taxi via Atlanta

    1. Take the bus from Port St Lucie to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to La Grange Bus Stationbus bus
    3. Take the bus from La Grange Bus Station to Mobilebus bus
    4. Take the bus from Loxley to Crestviewbus bus
    5. Take the taxi from Crestview to Destintaxi taxi
    20h 9m
    $317–439

  4. Bus to Orlando, fly to Pensacola International Airport, taxi

    1. Take the bus from Fort Pierce to Kissimmee -1471 East Osceola Parkwaybus bus
    2. Fly from Orlando (MCO) to Pensacola International Airport (PNS)plane plane MCO - PNS
    3. Take the taxi from Pensacola-Airport-PNS to Destintaxi taxi
    7h 11m
    $229–383

  5. Bus to Fort Lauderdale–Hollywood International Airport, fly to Pensacola International Airport, taxi

    1. Take the bus from Fort Pierce to Sheridan Tri-Rail Stationbus bus
    2. Fly from Fort Lauderdale–Hollywood International Airport (FLL) to Pensacola International Airport (PNS)plane plane FLL - PNS
    3. Take the taxi from Pensacola-Airport-PNS to Destintaxi taxi
    6h 46m
    $291–493

  6. Bus to Miami International Airport, fly to Pensacola International Airport, taxi

    1. Take the bus from Fort Pierce to Sheridan Tri-Rail Stationbus bus
    2. Fly from Miami International Airport (MIA) to Pensacola International Airport (PNS)plane plane MIA - PNS
    3. Take the taxi from Pensacola-Airport-PNS to Destintaxi taxi
    7h 2m
    $198–474

  7. Bus, taxi to Melbourne International Airport, fly to Destin–Fort Walton Beach Airport

    1. Take the bus from Fort Pierce to Sebastianbus bus
    2. Take the taxi from Sebastian to Melbourne International Airport (MLB)taxi taxi
    3. Fly from Melbourne International Airport (MLB) to Destin–Fort Walton Beach Airport (VPS)plane plane MLB - VPS
    9h 45m
    $200–563

  8. Bus to Miami International Airport, fly to Tallahassee, drive

    1. Take the bus from Fort Pierce to Sheridan Tri-Rail Stationbus bus
    2. Fly from Miami International Airport (MIA) to Tallahassee (TLH)plane plane MIA - TLH
    3. Drive from Tallahassee (TLH) to Destincar car
    8h 19m
    $118–454

  9. Bus, taxi

    1. Take the bus from Fort Pierce to Kissimmee -1471 East Osceola Parkwaybus bus
    2. Take the bus from Kissimmee -1471 East Osceola Parkway to Tallahassee - FSU - Old St Augustine at Intramural Fieldbus bus
    3. Take the bus from Tallahassee to Montgomery Intermodal Centerbus bus
    4. Take the bus from Montgomery to Mobilebus bus
    5. Take the bus from Loxley to Crestviewbus bus
    6. Take the taxi from Crestview to Destintaxi taxi
    20h 40m
    $329–447

  10. Bus, taxi via Jacksonville

    1. Take the bus from Fort Pierce to Jacksonvillebus bus
    2. Take the bus from Jacksonville to La Grange Bus Stationbus bus
    3. Take the bus from La Grange Bus Station to Mobilebus bus
    4. Take the bus from Loxley to Crestviewbus bus
    5. Take the taxi from Crestview to Destintaxi taxi
    24h 24m
    $298–409

Miami International Airport (MIA) to Destin–Fort Walton Beach Airport (VPS) flights

Calendar23Weekly Planes
Duration4hAverage Duration
Ticket$52Cheapest Price
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Comparing Your Travel Options

Map of how to get from Port Saint Lucie to Destin.ExpandLaunch map view
  • Distance: 634.4 mi
  • Duration: 6h 11m

What companies run services between Port Saint Lucie, FL, USA and Destin, FL, USA?

There is no direct connection from Port Saint Lucie to Destin. However, you can take the bus to Sheridan Tri-Rail Station, walk to Sheridan Street Station, take the train to Miami Airport Station, walk to Miami, Airport Intermodal Station, take the vehicle to Miami International Airport, walk to Miami International Airport (MIA) airport, fly to Destin–Fort Walton Beach Airport (VPS), then take the taxi to Destin. Alternatively, you can take the taxi to Port St Lucie, take the bus to Atlanta Bus Station, take the bus to La Grange Bus Station, take the bus to Mobile, take the bus to Crestview, then take the taxi to Destin.

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