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How to get fromPort Saint Lucie to Florenceby bus (Flixbus), bus, train, car, taxi, plane, or bus (Greyhound)

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There are 5 ways to get from Port Saint Lucie to Florence by bus (Flixbus), bus, train, car, taxi, plane, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Fort Pierce to Orlandobus bus Miami to Orlando
    2. Take the bus from Orlando Bus Station to Florencebus bus FlixBus N2472
    13h 14m
    $118–180

  2. Bus via Jacksonville (Greyhound)

    cheapest
    1. Take the bus from Fort Pierce to Jacksonvillebus bus
    2. Take the bus from Jacksonville to Sumter Bus Stopbus bus
    3. Take the bus from Sumter Bus Stop to Florence Bus Stationbus bus
    17h 41m
    $85–169

  3. Bus, train

    1. Take the bus from Fort Pierce to Kissimmee -1471 East Osceola Parkwaybus bus Miami to Orlando
    2. Take the train from Kissimmee Amtrak Station to Florence Stationtrain train Silver Meteor
    14h 20m
    $192–381

  4. Drive 539.6 mi

    1. Drive from Port Saint Lucie to Florencecar car 539.6 mi
    8h 54m
    $99–143

  5. Taxi, fly

    1. Take the taxi from Port Saint Lucie to Vero Beach Municipal Airport (VRB)taxi taxi
    2. Fly from Vero Beach Municipal Airport (VRB) to Florence Regional Airport (FLO)plane plane VRB - FLO
    8h 1m
    $182–552

Port Saint Lucie to Florence by bus and train

Calendar7Weekly Services
Duration14h 20mAverage Duration
Ticket$192Cheapest Price
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Questions & Answers

Map of how to get from Port Saint Lucie to Florence.ExpandLaunch map view
  • Distance: 587.6 mi
  • Duration: 13h 14m

What companies run services between Port Saint Lucie, FL, USA and Florence, SC, USA?

You can take a bus from Fort Pierce to Florence via L B Mcleod Rd & Gardenia Ave, N Garland Ave & W Amelia St, N John Young Pkwy & Business Center Blvd, Orlando Bus Station, and Florence in around 13h 14m.

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