There are 6 ways to get from Port Saint Lucie to Florida Keys by bus (Greyhound), car, bus, plane, or shuttle
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus
best- Take the bus from Fort Pierce to Sheridan Tri-Rail Stationbus Orlando to Miami
- Take the bus from Miami Airport Station to Big Pine Keybus Greyhound US0720s
8h 55m$58–83Drive 257.2 mi
cheapest- Drive from Port Saint Lucie to Florida Keyscar 257.2 mi
5h 1m$44–64Bus to Miami International Airport, fly
- Take the bus from Fort Pierce to Sheridan Tri-Rail Stationbus
- Fly from Miami International Airport (MIA) to Key West International Airport (EYW)plane MIA - EYW
7h 41m$134–318Bus, shuttle
- Take the bus from Fort Pierce to Miami International Airportbus Orlando to Miami
- Take a shuttle bus from Miami, FL - International Airport to Summerland Key - Mote Marine LabTo the Keys
9h 7m$184–224Drive to Orlando Sanford, fly
- Drive from Port Saint Lucie to Orlando-Sanford-Airport-SFBcar
- Fly from Orlando Sanford (SFB) to Key West International Airport (EYW)plane SFB - EYW
6h 43m$134–366Bus to Orlando, fly
- Take the bus from Fort Pierce to Kissimmee -1471 East Osceola Parkwaybus
- Fly from Orlando (MCO) to Key West International Airport (EYW)plane MCO - EYW
8h 30m$176–837
Port Saint Lucie to Florida Keys by bus and foot
Comparing Your Travel Options
The cheapest way to get from Port Saint Lucie to Florida Keys is to drive which costs $40 - $65 and takes 5h 1m.
The fastest way to get from Port Saint Lucie to Florida Keys is to drive which takes 5h 1m and costs $40 - $65.
No, there is no direct bus from Port Saint Lucie to Florida Keys. However, there are services departing from Fort Pierce and arriving at Sugarloaf Key - Lower - Sugarloaf Lodge via Hollywood Sheridan Trirail Station, Miami Airport Station and Big Pine Key - CVS / MM30. The journey, including transfers, takes approximately 8h 55m.
The distance between Port Saint Lucie and Florida Keys is 260 miles. The road distance is 258.7 miles.
The best way to get from Port Saint Lucie to Florida Keys without a car is to bus which takes 8h 55m and costs $55 - $85.
It takes approximately 8h 55m to get from Port Saint Lucie to Florida Keys, including transfers.
Port Saint Lucie to Florida Keys bus services, operated by Jet Set Express, depart from Fort Pierce station.
Port Saint Lucie to Florida Keys bus services, operated by Jet Set Express, arrive at Sheridan Tri-Rail Station.
Yes, the driving distance between Port Saint Lucie to Florida Keys is 259 miles. It takes approximately 5h 1m to drive from Port Saint Lucie to Florida Keys.
There are 958+ hotels available in Florida Keys.
What companies run services between Port Saint Lucie, FL, USA and Florida Keys, FL, USA?
You can take a bus from Fort Pierce to Florida Keys via Sheridan Tri-Rail Station, Hollywood Sheridan Trirail Station, Miami Airport Station, Big Pine Key, Big Pine Key - CVS / MM30, and Sugarloaf Key - Lower - Sugarloaf Lodge in around 8h 55m.
- Website
- aa.com
Flights from Miami International Airport to Key West International Airport
- Ave. Duration
- 1h 3m
- When
- Every day
- Estimated price
- $24–180
Flights from Orlando to Key West International Airport via Miami International Airport
- Ave. Duration
- 3h 30m
- When
- Every day
- Estimated price
- $35–230
- Website
- allegiantair.com
Flights from Orlando Sanford to Key West International Airport
- Ave. Duration
- 1h 20m
- When
- Friday, Monday, Thursday, and Sunday
- Estimated price
- $35–240
- Website
- flybreeze.com
Flights from Orlando to Key West International Airport
- Ave. Duration
- 1h 23m
- When
- Monday, Thursday, Friday, and Sunday
- Estimated price
- $65–700
- Phone
- (+1) 407 649 4994
- [email protected]
- Website
- Jet Set Express
Bus from Fort Pierce to Sheridan Tri-Rail Station
- Ave. Duration
- 1h 30m
- Frequency
- Twice daily
- Estimated price
- $30–40
- Website
- Jet Set Express
- Schedules at
- Jet Set Express
- Book at
- Jet Set Express
- Adult
- $30–40
Bus from Fort Pierce to Sheridan Tri-Rail Station
- Ave. Duration
- 1h 30m
- Frequency
- Twice daily
- Estimated price
- $30–40
- Website
- Jet Set Express
- Schedules at
- Jet Set Express
- Book at
- Jet Set Express
- Adult
- $30–40
Bus from Fort Pierce to Miami International Airport
- Ave. Duration
- 3h 25m
- Frequency
- Twice daily
- Estimated price
- $30–45
- Website
- Jet Set Express
- Schedules at
- Jet Set Express
- Book at
- Jet Set Express
- Adult
- $30–45
Bus from Fort Pierce to Kissimmee -1471 East Osceola Parkway
- Ave. Duration
- 1h 40m
- Frequency
- Twice daily
- Estimated price
- $30–40
- Website
- Jet Set Express
- Schedules at
- Jet Set Express
- Book at
- Jet Set Express
- Adult
- $30–40
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Miami Airport Station to Big Pine Key
- Ave. Duration
- 3h 40m
- Frequency
- 5 times a day
- Estimated price
- $23–35
- Website
- Greyhound
- Phone
- +1 (305) 289-9997
- [email protected]
- Website
- Keys Shuttle
Shuttle from Miami, FL - International Airport to Summerland Key - Mote Marine Lab
- Ave. Duration
- 3h 30m
- Frequency
- 3 times a day
- Estimated price
- $150–180
- Website
- Keys Shuttle
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