What is the cheapest way to get from Port Saint Lucie to Florida Keys?

The cheapest way to get from Port Saint Lucie to Florida Keys is to drive which costs $40 - $65 and takes 5h 1m.

What is the fastest way to get from Port Saint Lucie to Florida Keys?

The fastest way to get from Port Saint Lucie to Florida Keys is to drive which takes 5h 1m and costs $40 - $65.

Is there a direct bus between Port Saint Lucie and Florida Keys?

No, there is no direct bus from Port Saint Lucie to Florida Keys. However, there are services departing from Fort Pierce and arriving at Sugarloaf Key - Lower - Sugarloaf Lodge via Hollywood Sheridan Trirail Station, Miami Airport Station and Big Pine Key - CVS / MM30. The journey, including transfers, takes approximately 9h 5m.

How far is it from Port Saint Lucie to Florida Keys?

The distance between Port Saint Lucie and Florida Keys is 260 miles. The road distance is 258.7 miles.

How do I travel from Port Saint Lucie to Florida Keys without a car?

The best way to get from Port Saint Lucie to Florida Keys without a car is to bus which takes 9h 5m and costs $55 - $85.

How long does it take to get from Port Saint Lucie to Florida Keys?

It takes approximately 9h 5m to get from Port Saint Lucie to Florida Keys, including transfers.

Where do I catch the Port Saint Lucie to Florida Keys bus from?

Port Saint Lucie to Florida Keys bus services, operated by Jet Set Express, depart from Fort Pierce station.

Where does the Port Saint Lucie to Florida Keys bus arrive?

Port Saint Lucie to Florida Keys bus services, operated by Jet Set Express, arrive at Sheridan Tri-Rail Station.

Can I drive from Port Saint Lucie to Florida Keys?

Yes, the driving distance between Port Saint Lucie to Florida Keys is 259 miles. It takes approximately 5h 1m to drive from Port Saint Lucie to Florida Keys.

Where can I stay near Florida Keys?

There are 958+ hotels available in Florida Keys.

Port Saint Lucie to Florida Keys - 7 ways to travel via bus, car, and plane

How to get fromPort Saint Lucie to Florida Keys

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There are 7 ways to get from Port Saint Lucie to Florida Keys by bus (Greyhound), car, bus, plane, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

Bus
best
1. Take the bus from Fort Pierce to Sheridan Tri-Rail Stationbus Orlando to Miami
2. Take the bus from Miami Airport Station to Big Pine Keybus Greyhound US0720s
9h 5m
$57–83
Drive 257.2 mi
cheapest
1. Drive from Port Saint Lucie to Florida Keyscar 257.2 mi
5h 1m
$43–62
Bus to Miami International Airport, fly
1. Take the bus from Fort Pierce to Sheridan Tri-Rail Stationbus
2. Fly from Miami International Airport (MIA) to Key West International Airport (EYW)plane MIA - EYW
7h 41m
$135–328
Bus, shuttle
1. Take the bus from Fort Pierce to Miami International Airportbus Orlando to Miami
2. Take a shuttle bus from Miami, FL - International Airport to Summerland Key - Mote Marine Labshuttle To the Keys
9h 7m
$184–224
Drive to Orlando Sanford, fly
1. Drive from Port Saint Lucie to Orlando-Sanford-Airport-SFBcar
2. Fly from Orlando Sanford (SFB) to Key West International Airport (EYW)plane SFB - EYW
6h 43m
$134–375
Bus to Orlando, fly
1. Take the bus from Fort Pierce to Kissimmee -1471 East Osceola Parkwaybus
2. Fly from Orlando (MCO) to Key West International Airport (EYW)plane MCO - EYW
8h 30m
$176–607
Bus to Tampa, fly
1. Take the bus from Port St Lucie to Tampa Bus Stationbus
2. Fly from Tampa (TPA) to Key West International Airport (EYW)plane TPA - EYW
10h 37m
$230–783

Port Saint Lucie to Florida Keys by bus and foot

14Weekly Services

9h 5mAverage Duration

$57Cheapest Price

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Comparing Your Travel Options

Map of how to get from Port Saint Lucie to Florida Keys.

Launch map view

Distance: 258.6 mi
Duration: 9h 5m

What companies run services between Port Saint Lucie, FL, USA and Florida Keys, FL, USA?

You can take a bus from Fort Pierce to Florida Keys via Sheridan Tri-Rail Station, Hollywood Sheridan Trirail Station, Miami Airport Station, Big Pine Key, Big Pine Key - CVS / MM30, and Sugarloaf Key - Lower - Sugarloaf Lodge in around 9h 5m.

Airlines

Bus operators

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How to get fromPort Saint Lucie to Florida Keysby bus (Greyhound), car, bus, plane, or shuttle

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There are 7 ways to get from Port Saint Lucie to Florida Keys by bus (Greyhound), car, bus, plane, or shuttle

Bus

Drive 257.2 mi

Bus to Miami International Airport, fly

Bus, shuttle

Drive to Orlando Sanford, fly

Bus to Orlando, fly

Bus to Tampa, fly