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How to get fromPort Saint Lucie to Florida Panhandleby bus, car, or plane

Find Transport to Florida Panhandle

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There are 8 ways to get from Port Saint Lucie to Florida Panhandle by bus, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, drive

    best
    1. Take the bus from Fort Pierce to Kissimmee -1471 East Osceola Parkwaybus bus
    2. Take the bus from Kissimmee -1471 East Osceola Parkway to Tallahassee - FSU - Old St Augustine at Intramural Fieldbus bus
    3. Drive from Tallahassee - FSU - Old St Augustine at Intramural Field to Florida Panhandlecar car
    9h 24m
    $105–184

  2. Drive 412.5 mi

    cheapest
    1. Drive from Port Saint Lucie to Florida Panhandlecar car 412.5 mi
    7h 30m
    $76–109

  3. Bus to Miami International Airport, fly to Tallahassee, drive

    1. Take the bus from Fort Pierce to Sheridan Tri-Rail Stationbus bus
    2. Fly from Miami International Airport (MIA) to Tallahassee (TLH)plane plane MIA - TLH
    3. Drive from Tallahassee (TLH) to Florida Panhandlecar car
    6h 37m
    $108–449

  4. Bus, drive via Orlando

    1. Take the bus from Fort Pierce to Kissimmee -1471 East Osceola Parkwaybus bus
    2. Take the bus from Orlando to Tallahasseebus bus
    3. Drive from Capital Circle NW and Commonwealth Boulevard to Florida Panhandlecar car
    12h 1m
    $84–133

  5. Bus to President Donald J. Trump International Airport, fly to Tallahassee, drive

    1. Take the bus from GATLIN BLVD at I-95 P/R LOT to WPB ITC at TRI RAILbus bus
    2. Fly from President Donald J. Trump International Airport (PBI) to Tallahassee (TLH)plane plane PBI - TLH
    3. Drive from Tallahassee (TLH) to Florida Panhandlecar car
    8h 40m
    $485–906

  6. Bus to President Donald J. Trump International Airport, fly to Northwest Florida Beaches International Airport, drive

    1. Take the bus from GATLIN BLVD at I-95 P/R LOT to WPB ITC at TRI RAILbus bus
    2. Fly from President Donald J. Trump International Airport (PBI) to Northwest Florida Beaches International Airport (ECP)plane plane PBI - ECP
    3. Drive from Northwest Florida Beaches International Airport (ECP) to Florida Panhandlecar car
    8h 24m
    $135–516

  7. Bus to Fort Lauderdale–Hollywood International Airport, fly to Tallahassee, drive

    1. Take the bus from Fort Pierce to Sheridan Tri-Rail Stationbus bus
    2. Fly from Fort Lauderdale–Hollywood International Airport (FLL) to Tallahassee (TLH)plane plane FLL - TLH
    3. Drive from Tallahassee (TLH) to Florida Panhandlecar car
    6h 15m
    $251–908

  8. Bus to Miami International Airport, fly to Destin–Fort Walton Beach Airport, drive

    1. Take the bus from Fort Pierce to Sheridan Tri-Rail Stationbus bus
    2. Fly from Miami International Airport (MIA) to Destin–Fort Walton Beach Airport (VPS)plane plane MIA - VPS
    3. Drive from Destin–Fort Walton Beach Airport (VPS) to Florida Panhandlecar car
    7h 51m
    $106–391

Miami International Airport (MIA) to Tallahassee (TLH) flights

Calendar28Weekly Planes
Duration1h 33mAverage Duration
Ticket$65Cheapest Price
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Questions & Answers

Map of how to get from Port Saint Lucie to Florida Panhandle.ExpandLaunch map view
  • Distance: 436.9 mi
  • Duration: 9h 24m

What companies run services between Port Saint Lucie, FL, USA and Florida Panhandle, FL, USA?

There is no direct connection from Port Saint Lucie to Florida Panhandle. However, you can take the bus to Kissimmee -1471 East Osceola Parkway, take the bus to Tallahassee - FSU - Old St Augustine at Intramural Field, then drive to Florida Panhandle. Alternatively, you can drive from Port Saint Lucie to Florida Panhandle in around 7h 30m.

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