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How to get fromPort Saint Lucie to Great Smoky Mountainsby car, plane, bus, or train

Find Transport to Great Smoky Mountains

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There are 9 ways to get from Port Saint Lucie to Great Smoky Mountains by car, plane, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Orlando Sanford, fly to Mcghee Tyson Airport, drive

    best
    1. Drive from Port Saint Lucie to Orlando-Sanford-Airport-SFBcar car
    2. Fly from Orlando Sanford (SFB) to Mcghee Tyson Airport (TYS)plane plane SFB - TYS
    3. Drive from Mcghee Tyson Airport (TYS) to Great Smoky Mountainscar car
    6h 1m
    $154–751

  2. Drive to Orlando Sanford, fly to Asheville Regional Airport, drive

    cheapest
    1. Drive from Port Saint Lucie to Orlando-Sanford-Airport-SFBcar car
    2. Fly from Orlando Sanford (SFB) to Asheville Regional Airport (AVL)plane plane SFB - AVL
    3. Drive from Asheville-Airport-AVL to Great Smoky Mountainscar car
    6h 14m
    $93–407

  3. Bus, drive

    1. Take the bus from Fort Pierce to Orlandobus bus
    2. Take the bus from Orlando Bus Station to Raleigh Bus Stationbus bus
    3. Take the bus from Raleigh Bus Station to Asheville, NCbus bus
    4. Drive from Asheville, NC to Great Smoky Mountainscar car
    23h 56m
    $171–287

  4. Bus, train, drive

    1. Take the bus from Fort Pierce to Kissimmee -1471 East Osceola Parkwaybus bus
    2. Take the train from Kissimmee Amtrak Station to Carytrain train
    3. Take the train from Cary to Greensborotrain train
    4. Take the bus from Greensboro Bus Stop to Asheville, NCbus bus
    5. Drive from Asheville, NC to Great Smoky Mountainscar car
    26h 49m
    $282–581

  5. Drive 679.2 mi

    1. Drive from Port Saint Lucie to Great Smoky Mountainscar car 679.2 mi
    14h 2m
    $124–179

  6. Bus to President Donald J. Trump International Airport, fly to Asheville Regional Airport, drive

    1. Take the bus from GATLIN BLVD at I-95 P/R LOT to WPB ITC at TRI RAILbus bus
    2. Fly from President Donald J. Trump International Airport (PBI) to Asheville Regional Airport (AVL)plane plane PBI - AVL
    3. Drive from Asheville-Airport-AVL to Great Smoky Mountainscar car
    7h 15m
    $129–503

  7. Bus to Orlando, fly to Mcghee Tyson Airport, drive

    1. Take the bus from Fort Pierce to Kissimmee -1471 East Osceola Parkwaybus bus
    2. Fly from Orlando (MCO) to Mcghee Tyson Airport (TYS)plane plane MCO - TYS
    3. Drive from Mcghee Tyson Airport (TYS) to Great Smoky Mountainscar car
    7h 46m
    $154–709

  8. Bus to Fort Lauderdale–Hollywood International Airport, fly to Mcghee Tyson Airport, drive

    1. Take the bus from Fort Pierce to Sheridan Tri-Rail Stationbus bus
    2. Fly from Fort Lauderdale–Hollywood International Airport (FLL) to Mcghee Tyson Airport (TYS)plane plane FLL - TYS
    3. Drive from Mcghee Tyson Airport (TYS) to Great Smoky Mountainscar car
    7h 23m
    $181–859

  9. Bus to Fort Lauderdale–Hollywood International Airport, fly to Asheville Regional Airport, drive

    1. Take the bus from Fort Pierce to Sheridan Tri-Rail Stationbus bus
    2. Fly from Fort Lauderdale–Hollywood International Airport (FLL) to Asheville Regional Airport (AVL)plane plane FLL - AVL
    3. Drive from Asheville-Airport-AVL to Great Smoky Mountainscar car
    7h 33m
    $115–455

Orlando Sanford (SFB) to Mcghee Tyson Airport (TYS) flights

Calendar11Weekly Planes
Duration1h 38mAverage Duration
Ticket$120Cheapest Price
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Questions & Answers

Map of how to get from Port Saint Lucie to Great Smoky Mountains.ExpandLaunch map view
  • Distance: 702.1 mi
  • Duration: 6h 1m

What companies run services between Port Saint Lucie, FL, USA and Great Smoky Mountains, TN, USA?

There is no direct connection from Port Saint Lucie to Great Smoky Mountains. However, you can drive to Orlando-Sanford-Airport-SFB airport, fly to Mcghee Tyson Airport (TYS), then drive to Great Smoky Mountains. Alternatively, you can take a bus from Fort Pierce to Great Smoky Mountains via L B Mcleod Rd & Gardenia Ave, N Garland Ave & W Amelia St, N John Young Pkwy & Business Center Blvd, Orlando Bus Station, Raleigh Bus Station, and Asheville, NC in around 23h 56m.

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