There are 6 ways to get from Port Saint Lucie to Key West by bus, plane, bus (Greyhound), car, or shuttle
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus to Miami International Airport, fly
best- Take the bus from Fort Pierce to Sheridan Tri-Rail Stationbus
- Fly from Miami International Airport (MIA) to Key West International Airport (EYW)plane MIA - EYW
4h 54m$68–237Drive 272.7 mi
cheapest- Drive from Port Saint Lucie to Key Westcar 272.7 mi
5h 24m$47–68Bus
- Take the bus from Fort Pierce to Sheridan Tri-Rail Stationbus
- Take the bus from Miami Airport Station to Big Pine Keybus
- Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus Lks
9h 42m$58–83Bus, shuttle
- Take the bus from Fort Pierce to Miami International Airportbus Orlando to Miami
- Take a shuttle bus from Miami, FL - International Airport to Key West, FLTo the Keys
9h 31m$204–244Drive to Orlando Sanford, fly
- Drive from Port Saint Lucie to Orlando-Sanford-Airport-SFBcar
- Fly from Orlando Sanford (SFB) to Key West International Airport (EYW)plane SFB - EYW
3h 57m$68–285Bus to Orlando, fly
- Take the bus from Fort Pierce to Kissimmee -1471 East Osceola Parkwaybus
- Fly from Orlando (MCO) to Key West International Airport (EYW)plane MCO - EYW
5h 44m$110–756
Port Saint Lucie to Key West by bus and foot
Comparing Your Travel Options
The cheapest way to get from Port Saint Lucie to Key West is to drive which costs $45 - $70 and takes 5h 24m.
The fastest way to get from Port Saint Lucie to Key West is to drive and fly which takes 3h 57m and costs $65 - $290.
No, there is no direct bus from Port Saint Lucie to Key West. However, there are services departing from Fort Pierce and arriving at N Roosevelt & 3rd Street via Hollywood Sheridan Trirail Station, Miami Airport Station and Big Pine Key - CVS / MM30. The journey, including transfers, takes approximately 9h 42m.
The distance between Port Saint Lucie and Key West is 246 miles. The road distance is 274.2 miles.
The best way to get from Port Saint Lucie to Key West without a car is to bus which takes 9h 42m and costs $55 - $85.
It takes approximately 4h 54m to get from Port Saint Lucie to Key West, including transfers.
Port Saint Lucie to Key West bus services, operated by Jet Set Express, depart from Fort Pierce station.
Port Saint Lucie to Key West bus services, operated by Jet Set Express, arrive at Sheridan Tri-Rail Station.
Yes, the driving distance between Port Saint Lucie to Key West is 274 miles. It takes approximately 5h 24m to drive from Port Saint Lucie to Key West.
Book your Port Saint Lucie to Key West bus tickets online with Omio.
What companies run services between Port Saint Lucie, FL, USA and Key West, FL, USA?
You can take a bus from Fort Pierce to N Roosevelt & 3rd Street via Sheridan Tri-Rail Station, Hollywood Sheridan Trirail Station, Miami Airport Station, Big Pine Key, and Big Pine Key - CVS / MM30 in around 9h 42m.
- Website
- aa.com
Flights from Miami International Airport to Key West International Airport
- Ave. Duration
- 1h 3m
- When
- Every day
- Estimated price
- $24–180
Flights from Orlando to Key West International Airport via Miami International Airport
- Ave. Duration
- 3h 30m
- When
- Every day
- Estimated price
- $35–230
- Website
- allegiantair.com
Flights from Orlando Sanford to Key West International Airport
- Ave. Duration
- 1h 20m
- When
- Friday, Monday, Thursday, and Sunday
- Estimated price
- $35–240
- Website
- flybreeze.com
Flights from Orlando to Key West International Airport
- Ave. Duration
- 1h 23m
- When
- Monday, Thursday, Friday, and Sunday
- Estimated price
- $65–700
- Phone
- (+1) 407 649 4994
- [email protected]
- Website
- Jet Set Express
Bus from Fort Pierce to Sheridan Tri-Rail Station
- Ave. Duration
- 1h 30m
- Frequency
- Twice daily
- Estimated price
- $30–40
- Website
- Jet Set Express
- Schedules at
- Jet Set Express
- Book at
- Jet Set Express
- Adult
- $30–40
Bus from Fort Pierce to Sheridan Tri-Rail Station
- Ave. Duration
- 1h 30m
- Frequency
- Twice daily
- Estimated price
- $30–40
- Website
- Jet Set Express
- Schedules at
- Jet Set Express
- Book at
- Jet Set Express
- Adult
- $30–40
Bus from Fort Pierce to Miami International Airport
- Ave. Duration
- 3h 25m
- Frequency
- Twice daily
- Estimated price
- $30–45
- Website
- Jet Set Express
- Schedules at
- Jet Set Express
- Book at
- Jet Set Express
- Adult
- $30–45
Bus from Fort Pierce to Kissimmee -1471 East Osceola Parkway
- Ave. Duration
- 1h 40m
- Frequency
- Twice daily
- Estimated price
- $30–40
- Website
- Jet Set Express
- Schedules at
- Jet Set Express
- Book at
- Jet Set Express
- Adult
- $30–40
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Miami Airport Station to Big Pine Key
- Ave. Duration
- 3h 40m
- Frequency
- 5 times a day
- Estimated price
- $23–35
- Website
- Greyhound
- Phone
- +1 305-809-3700
- Website
- cityofkeywest-fl.gov
Bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Street
- Ave. Duration
- 1h 9m
- Frequency
- Every 3 hours
- Estimated price
- $2–4
- Schedules at
- Key West Transit
- Phone
- +1 (305) 289-9997
- [email protected]
- Website
- Keys Shuttle
Shuttle from Miami, FL - International Airport to Key West, FL
- Ave. Duration
- 4h
- Frequency
- 3 times a day
- Estimated price
- $170–200
- Website
- Keys Shuttle
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Booking & Getting There
There are 958+ hotels available in Key West.