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How to get fromPort Saint Lucie to Key Westby bus, train, plane, bus (Greyhound), car, or shuttle

Find Transport to Key West

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There are 7 ways to get from Port Saint Lucie to Key West by bus, train, plane, bus (Greyhound), car, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, train to Miami International Airport, fly

    best
    1. Take the bus from Fort Pierce to Sheridan Tri-Rail Stationbus bus
    2. Take the train from Sheridan Street Station to Miami Airport Stationtrain train
    3. Fly from Miami International Airport (MIA) to Key West International Airport (EYW)plane plane MIA - EYW
    4h 49m
    $73–277

  2. Drive  272.7 mi

    cheapest
    1. Drive from Port Saint Lucie to Key Westcar car 272.7 mi
    5h 24m
    $50–72

  3. Bus

    1. Take the bus from Fort Pierce to Miami International Airportbus bus
    2. Take the bus from Miami Airport Station to Big Pine Keybus bus
    3. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    10h 27m
    $54–79

  4. Bus, shuttle

    1. Take the bus from Fort Pierce to Miami International Airportbus bus Orlando to Miami
    2. Take a shuttle bus from Miami, FL - International Airport to Key West, FLshuttle bus To the Keys
    9h 31m
    $204–244

  5. Drive to Orlando Sanford, fly

    1. Drive from Port Saint Lucie to Orlando-Sanford-Airport-SFBcar car
    2. Fly from Orlando Sanford (SFB) to Key West International Airport (EYW)plane plane SFB - EYW
    3h 50m
    $70–308

  6. Bus to Orlando, fly

    1. Take the bus from Fort Pierce to Kissimmee -1471 East Osceola Parkwaybus bus
    2. Fly from Orlando (MCO) to Key West International Airport (EYW)plane plane MCO - EYW
    5h 44m
    $110–706

  7. Bus to Tampa, fly

    1. Take the bus from Port St Lucie to Tampa Bus Stationbus bus
    2. Fly from Tampa (TPA) to Key West International Airport (EYW)plane plane TPA - EYW
    7h 50m
    $124–432

Port Saint Lucie to Key West by bus, tram, and foot

Calendar14Weekly Services
Duration10h 27mAverage Duration
Ticket$54Cheapest Price
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Comparing Your Travel Options

Map of how to get from Port Saint Lucie to Key West.ExpandLaunch map view
  • Distance: 244.9 mi
  • Duration: 4h 49m

What companies run services between Port Saint Lucie, FL, USA and Key West, FL, USA?

You can take a bus from Fort Pierce to N Roosevelt & 3rd Street via Miami International Airport, Miami International Airport, Miami, Airport Intermodal Station, Miami Airport Station, Big Pine Key, and Big Pine Key - CVS / MM30 in around 10h 27m.

Airlines
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Bus operators

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