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How to get fromPort Saint Lucie to Key West, FLby bus, shuttle, car, or plane

Find Transport to Key West, FL

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There are 7 ways to get from Port Saint Lucie to Key West, FL by bus, shuttle, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, shuttle via Big Pine Key

    best
    1. Take the bus from Fort Pierce to Sheridan Tri-Rail Stationbus bus
    2. Take the bus from Miami Airport Station to Big Pine Keybus bus
    3. Take a shuttle bus from Big Pine Key, FL to Key West, FLshuttle bus
    8h 51m
    $142–194

  2. Drive 274.1 mi

    cheapest
    1. Drive from Port Saint Lucie to Key West, FLcar car 274.1 mi
    5h 27m
    $50–73

  3. Bus to Miami International Airport, fly

    1. Take the bus from Fort Pierce to Sheridan Tri-Rail Stationbus bus
    2. Fly from Miami International Airport (MIA) to Key West International Airport (EYW)plane plane MIA - EYW
    6h 3m
    $135–344

  4. Bus, shuttle

    1. Take the bus from Fort Pierce to Miami International Airportbus bus Orlando to Miami
    2. Take a shuttle bus from Miami, FL - International Airport to Key West, FLshuttle bus To the Keys
    8h 25m
    $202–240

  5. Bus to Orlando, fly

    1. Take the bus from Fort Pierce to Kissimmee -1471 East Osceola Parkwaybus bus
    2. Fly from Orlando (MCO) to Key West International Airport (EYW)plane plane MCO - EYW
    6h 45m
    $179–783

  6. Drive to Orlando Sanford, fly

    1. Drive from Port Saint Lucie to Orlando-Sanford-Airport-SFBcar car
    2. Fly from Orlando Sanford (SFB) to Key West International Airport (EYW)plane plane SFB - EYW
    5h 5m
    $134–375

  7. Bus to Tampa, fly

    1. Take the bus from Port St Lucie to Tampa Bus Stationbus bus
    2. Fly from Tampa (TPA) to Key West International Airport (EYW)plane plane TPA - EYW
    9h 4m
    $208–579

Port Saint Lucie to Key West, FL by bus, train, and shuttle

Calendar7Weekly Services
Duration8h 51mAverage Duration
Ticket$142Cheapest Price
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Questions & Answers

Map of how to get from Port Saint Lucie to Key West, FL.ExpandLaunch map view
  • Distance: 272.6 mi
  • Duration: 8h 51m

What companies run services between Port Saint Lucie, FL, USA and Key West, FL, USA?

There is no direct connection from Port Saint Lucie to Key West, FL. However, you can take the bus to Sheridan Tri-Rail Station, walk to Sheridan Street Station, take the train to Miami Airport Station, walk to Miami, Airport Intermodal Station, take the bus to Big Pine Key, walk to Big Pine Key, FL, then take the shuttle to Key West, FL. Alternatively, you can drive from Port Saint Lucie to Key West, FL in around 5h 27m.

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