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How to get fromPort Saint Lucie to Knoxvilleby car, plane, bus, train, or bus (Flixbus)

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There are 9 ways to get from Port Saint Lucie to Knoxville by car, plane, bus, train, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Orlando Sanford, fly to Mcghee Tyson Airport

    best
    1. Drive from Port Saint Lucie to Orlando-Sanford-Airport-SFBcar car
    2. Fly from Orlando Sanford (SFB) to Mcghee Tyson Airport (TYS)plane plane SFB - TYS
    4h 26m
    $189–755

  2. Drive to Orlando Sanford, fly to Asheville Regional Airport, drive

    cheapest
    1. Drive from Port Saint Lucie to Orlando-Sanford-Airport-SFBcar car
    2. Fly from Orlando Sanford (SFB) to Asheville Regional Airport (AVL)plane plane SFB - AVL
    3. Drive from Asheville-Airport-AVL to Knoxvillecar car
    6h 22m
    $101–410

  3. Bus, train via Farragut

    1. Take the bus from Fort Pierce to Kissimmee -1471 East Osceola Parkwaybus bus
    2. Take the train from Kissimmee Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York to Knoxvillebus bus Nyc
    40h 21m
    $575–1,044

  4. Bus

    1. Take the bus from Port St Lucie to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to New York City Chinatownbus bus
    3. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    46h 17m
    $355–551

  5. Drive 751 mi

    1. Drive from Port Saint Lucie to Knoxvillecar car 751 mi
    12h 32m
    $138–198

  6. Bus to Orlando, fly to Mcghee Tyson Airport

    1. Take the bus from Fort Pierce to Kissimmee -1471 East Osceola Parkwaybus bus
    2. Fly from Orlando (MCO) to Mcghee Tyson Airport (TYS)plane plane MCO - TYS
    6h 12m
    $189–713

  7. Bus to Fort Lauderdale–Hollywood International Airport, fly to Mcghee Tyson Airport

    1. Take the bus from Fort Pierce to Sheridan Tri-Rail Stationbus bus
    2. Fly from Fort Lauderdale–Hollywood International Airport (FLL) to Mcghee Tyson Airport (TYS)plane plane FLL - TYS
    5h 48m
    $216–813

  8. Bus to Miami International Airport, fly to Mcghee Tyson Airport

    1. Take the bus from Fort Pierce to Sheridan Tri-Rail Stationbus bus
    2. Fly from Miami International Airport (MIA) to Mcghee Tyson Airport (TYS)plane plane MIA - TYS
    6h 13m
    $208–764

  9. Bus, train

    1. Take the bus from Fort Pierce to Kissimmee -1471 East Osceola Parkwaybus bus
    2. Take the train from Kissimmee Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    40h 25m
    $530–954

Orlando Sanford (SFB) to Mcghee Tyson Airport (TYS) flights

Calendar11Weekly Planes
Duration1h 38mAverage Duration
Ticket$110Cheapest Price
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Questions & Answers

Map of how to get from Port Saint Lucie to Knoxville.ExpandLaunch map view
  • Distance: 655.7 mi
  • Duration: 4h 26m

What companies run services between Port Saint Lucie, FL, USA and Knoxville, TN, USA?

You can take a vehicle from Port Saint Lucie to Knoxville Station Hall of Fame via Port St Lucie, Atlanta Bus Station, New York, NY, Knoxville, TN, Walmart, and Fountain City Superstop in around 46h 17m.

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