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How to get fromPort Saint Lucie to Lake Cityby bus (Greyhound), bus, train, or car

Find Transport to Lake City

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There are 4 ways to get from Port Saint Lucie to Lake City by bus (Greyhound), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus via Orlando

    best
    1. Take the bus from Fort Pierce to Orlandobus bus Miami to Orlando
    2. Take the bus from Orlando Bus Station to Lake City Bus Stationbus bus Greyhound US0630
    8h 27m
    $56–87

  2. Drive 268.9 mi

    cheapest
    1. Drive from Port Saint Lucie to Lake Citycar car 268.9 mi
    4h 22m
    $50–71

  3. Bus, train

    1. Take the bus from Fort Pierce to Kissimmee -1471 East Osceola Parkwaybus bus
    2. Take the train from Kissimmee Amtrak Station to Jacksonvilletrain train
    3. Take the bus from Jacksonville to Lake City Bus Stationbus bus
    10h 44m
    $92–172

  4. Bus

    1. Take the bus from Fort Pierce to University of Florida - 1956 Gale Lemerand Drbus bus Miami
    2. Take the bus from Gainesville Bus Stop to Lake City Bus Stationbus bus Greyhound US0630
    10h 45m
    $64–121

Port Saint Lucie to Lake City by bus

Calendar14Weekly Buses
Duration8h 27mAverage Duration
Ticket$56Cheapest Price
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Questions & Answers

Map of how to get from Port Saint Lucie to Lake City.ExpandLaunch map view
  • Distance: 281.9 mi
  • Duration: 8h 27m

What companies run services between Port Saint Lucie, FL, USA and Lake City, FL, USA?

You can take a bus from Fort Pierce to Lake City Bus Station via L B Mcleod Rd & Gardenia Ave, N Garland Ave & W Amelia St, N John Young Pkwy & Business Center Blvd, and Orlando Bus Station in around 8h 27m.

Train operators
Bus operators

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Need to know: Greyhound

Read the travel guideNeed to know: Greyhound