There are 6 ways to get from Port Saint Lucie to Lexington by car, plane, bus (Greyhound), bus, or bus (Flixbus, Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Drive to Melbourne International Airport, fly to Blue Grass Airport
best- Drive from Port Saint Lucie to Melbourne International Airport (MLB)car
- Fly from Melbourne International Airport (MLB) to Blue Grass Airport (LEX)plane MLB - LEX
7h 49m$173–868Drive 908.7 mi
cheapest- Drive from Port Saint Lucie to Lexingtoncar 908.7 mi
15h 27m$166–240Bus via Orlando
- Take the bus from Fort Pierce to Orlando RedCoach Stationbus
- Take the bus from Orlando RedCoach Station to Atlanta - Civic Center MARTA Stationbus
- Take the bus from Atlanta Bus Station to Lexington Bus Stopbus
19h 1m$213–417Bus to Orlando, fly to Louisville International Airport, drive
- Take the bus from Fort Pierce to Orlando RedCoach Stationbus
- Fly from Orlando (MCO) to Louisville International Airport (SDF)plane MCO - SDF
- Drive from Louisville-Airport-SDF to Lexingtoncar
6h 50m$314–875Bus to Fort Lauderdale–Hollywood International Airport, fly to Blue Grass Airport
- Take the bus from Fort Pierce to Fort Lauderdale Airportbus
- Fly from Fort Lauderdale–Hollywood International Airport (FLL) to Blue Grass Airport (LEX)plane FLL - LEX
7h 38m$205–944Bus
- Take the bus from Port St Lucie to Atlanta Bus Stationbus FlixBus N2401
- Take the bus from Atlanta Bus Station to Lexington Bus Stopbus Greyhound US0110
19h 12m$203–348
Melbourne International Airport (MLB) to Blue Grass Airport (LEX) flights
Questions & Answers
The cheapest way to get from Port Saint Lucie to Lexington is to drive which costs $160 - $240 and takes 15h 27m.
The fastest way to get from Port Saint Lucie to Lexington is to bus and fly and drive which takes 6h 50m and costs $310 - $900.
No, there is no direct bus from Port Saint Lucie to Lexington. However, there are services departing from Fort Pierce and arriving at Lexington Bus Stop via Orlando RedCoach Station and Atlanta Bus Station. The journey, including transfers, takes approximately 19h 1m.
The distance between Port Saint Lucie and Lexington is 805 miles. The road distance is 914 miles.
The best way to get from Port Saint Lucie to Lexington without a car is to bus via Orlando which takes 19h 1m and costs $210 - $420.
It takes approximately 7h 49m to get from Port Saint Lucie to Lexington, including transfers.
Port Saint Lucie to Lexington bus services, operated by RedCoach, depart from Fort Pierce station.
Port Saint Lucie to Lexington bus services, operated by RedCoach, arrive at Orlando RedCoach Station.
Yes, the driving distance between Port Saint Lucie to Lexington is 914 miles. It takes approximately 15h 27m to drive from Port Saint Lucie to Lexington.
Book your Port Saint Lucie to Lexington bus tickets online with Omio.
What companies run services between Port Saint Lucie, FL, USA and Lexington, KY, USA?
You can take a bus from Fort Pierce to Lexington via Orlando RedCoach Station, Atlanta - Civic Center MARTA Station, Civic Center Station, Garnett Station, Atlanta Bus Station, and Lexington Bus Stop in around 19h 1m.
- Website
- delta.com
Flights from Melbourne International Airport to Blue Grass Airport via Atlanta
- Ave. Duration
- 5h 28m
- When
- Every day
- Estimated price
- $160–850
Flights from Orlando to Louisville International Airport via Atlanta
- Ave. Duration
- 4h 11m
- When
- Every day
- Estimated price
- $100–500
Flights from Fort Lauderdale–Hollywood International Airport to Blue Grass Airport via Atlanta
- Ave. Duration
- 4h 32m
- When
- Every day
- Estimated price
- $180–900
- Website
- aa.com
Flights from Melbourne International Airport to Blue Grass Airport via Charlotte
- Ave. Duration
- 5h 12m
- When
- Every day
- Estimated price
- $160–850
Flights from Orlando to Louisville International Airport via Charlotte
- Ave. Duration
- 4h 30m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $100–550
Flights from Fort Lauderdale–Hollywood International Airport to Blue Grass Airport via Charlotte
- Ave. Duration
- 5h 1m
- When
- Every day
- Estimated price
- $180–900
- Website
- southwest.com
Flights from Orlando to Louisville International Airport
- Ave. Duration
- 2h 11m
- When
- Every day
- Estimated price
- $95–500
Flights from Orlando to Louisville International Airport via Nashville
- Ave. Duration
- 4h 21m
- When
- Saturday, Monday, Thursday, Friday, and Sunday
- Estimated price
- $100–550
- Website
- allegiantair.com
Flights from Fort Lauderdale–Hollywood International Airport to Blue Grass Airport
- Ave. Duration
- 2h 27m
- When
- Thursday and Sunday
- Estimated price
- $180–900
- Phone
- +1 877 733 0724
- Website
- redcoachusa.com
Bus from Fort Pierce to Orlando RedCoach Station
- Ave. Duration
- 1h 45m
- Frequency
- Every 4 hours
- Estimated price
- $27–55
- Website
- https://www.redcoachusa.com
Bus from Orlando RedCoach Station to Atlanta - Civic Center MARTA Station
- Ave. Duration
- 7h 15m
- Frequency
- Once daily
- Estimated price
- $100–210
- Website
- https://www.redcoachusa.com
Bus from Fort Pierce to Orlando RedCoach Station
- Ave. Duration
- 1h 45m
- Frequency
- Every 4 hours
- Estimated price
- $27–55
- Website
- https://www.redcoachusa.com
Bus from Fort Pierce to Fort Lauderdale Airport
- Ave. Duration
- 1h 40m
- Frequency
- Hourly
- Estimated price
- $22–45
- Website
- https://www.redcoachusa.com
- Website
- greyhound.com
Bus from Atlanta Bus Station to Lexington Bus Stop
- Ave. Duration
- 7h 40m
- Frequency
- Once daily
- Schedules at
- greyhound.com
Bus from Atlanta Bus Station to Lexington Bus Stop
- Ave. Duration
- 7h 40m
- Frequency
- Once daily
- Schedules at
- greyhound.com
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- greyhound.com
Bus from Atlanta Bus Station to Lexington Bus Stop
- Ave. Duration
- 7h 55m
- Frequency
- Once daily
- Estimated price
- $55–120
- Website
- https://www.greyhound.com/
Bus from Atlanta Bus Station to Lexington Bus Stop
- Ave. Duration
- 7h 55m
- Frequency
- Once daily
- Estimated price
- $55–120
- Website
- https://www.greyhound.com/
- Phone
- +1 (855) 626-8585
- Website
- https://www.flixbus.com
Bus from Port St Lucie to Atlanta Bus Station
- Ave. Duration
- 10h 10m
- Frequency
- Once daily
- Estimated price
- $90–160
- Schedules at
- flixbus.com
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Need to know: Greyhound
Read the travel guide
More Questions & Answers
There are 174+ hotels available in Lexington.







