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How to get fromPort Saint Lucie to Louisvilleby bus, plane, bus (Flixbus, Greyhound, Amtrak), car, or bus (Greyhound, Amtrak)

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There are 10 ways to get from Port Saint Lucie to Louisville by bus, plane, bus (Flixbus, Greyhound, Amtrak), car, or bus (Greyhound, Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Orlando, fly to Louisville International Airport

    best
    1. Take the bus from Fort Pierce to Kissimmee -1471 East Osceola Parkwaybus bus
    2. Fly from Orlando (MCO) to Louisville International Airport (SDF)plane plane MCO - SDF
    7h 36m
    $425–946

  2. Bus to Miami International Airport, fly to Louisville International Airport

    cheapest
    1. Take the bus from Fort Pierce to Sheridan Tri-Rail Stationbus bus
    2. Fly from Miami International Airport (MIA) to Louisville International Airport (SDF)plane plane MIA - SDF
    7h 36m
    $154–647

  3. Bus

    1. Take the bus from Port St Lucie to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Nashville Bus Stationbus bus
    3. Take the bus from Nashville to Louisville, KYbus bus
    19h 54m
    $181–306

  4. Drive 928.4 mi

    1. Drive from Port Saint Lucie to Louisvillecar car 928.4 mi
    16h 28m
    $170–245

  5. Bus to Fort Lauderdale–Hollywood International Airport, fly to Louisville International Airport

    1. Take the bus from Fort Pierce to Sheridan Tri-Rail Stationbus bus
    2. Fly from Fort Lauderdale–Hollywood International Airport (FLL) to Louisville International Airport (SDF)plane plane FLL - SDF
    7h 8m
    $312–846

  6. Bus to President Donald J. Trump International Airport, fly to Louisville International Airport

    1. Take the bus from GATLIN BLVD at I-95 P/R LOT to WPB ITC at BAY Dbus bus
    2. Fly from President Donald J. Trump International Airport (PBI) to Louisville International Airport (SDF)plane plane PBI - SDF
    8h 35m
    $181–757

  7. Bus to Tampa, fly to Louisville International Airport

    1. Take the bus from Port St Lucie to Tampa Bus Stationbus bus
    2. Fly from Tampa (TPA) to Louisville International Airport (SDF)plane plane TPA - SDF
    9h 48m
    $294–697

  8. Drive to Orlando Sanford, fly to Blue Grass Airport, drive

    1. Drive from Port Saint Lucie to Orlando-Sanford-Airport-SFBcar car
    2. Fly from Orlando Sanford (SFB) to Blue Grass Airport (LEX)plane plane SFB - LEX
    3. Drive from Lexington-Airport-LEX to Louisvillecar car
    5h 49m
    $187–854

  9. Bus to Orlando, fly to Covington, bus

    1. Take the bus from Fort Pierce to Kissimmee -1471 East Osceola Parkwaybus bus
    2. Fly from Orlando (MCO) to Covington (CVG)plane plane MCO - CVG
    3. Take the bus from Cincinnati - Downtown to Louisville, KY Bus Stationbus bus
    10h 16m
    $155–640

  10. Bus via Tallahassee

    1. Take the bus from Fort Pierce to Kissimmee -1471 East Osceola Parkwaybus bus
    2. Take the bus from Kissimmee -1471 East Osceola Parkway to Tallahassee - FSU - Old St Augustine at Intramural Fieldbus bus
    3. Take the bus from Tallahassee to Nashville Bus Stationbus bus
    4. Take the bus from Nashville to Louisville, KYbus bus
    24h 39m
    $197–361

Orlando (MCO) to Louisville International Airport (SDF) flights

Calendar65Weekly Planes
Duration3h 45mAverage Duration
Ticket$101Cheapest Price
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Questions & Answers

Map of how to get from Port Saint Lucie to Louisville.ExpandLaunch map view
  • Distance: 862 mi
  • Duration: 7h 36m

What companies run services between Port Saint Lucie, FL, USA and Louisville, KY, USA?

You can take a vehicle from Port Saint Lucie to Louisville, KY via Port St Lucie, Atlanta Bus Station, and Nashville in around 19h 54m.

Airlines
Bus operators

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