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How to get fromPort Saint Lucie to Mayo Clinicby bus, plane, bus (Flixbus, Greyhound), train, or car

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There are 9 ways to get from Port Saint Lucie to Mayo Clinic by bus, plane, bus (Flixbus, Greyhound), train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to President Donald J. Trump International Airport, fly to Rochester

    best
    1. Take the bus from GATLIN BLVD at I-95 P/R LOT to WPB ITC at BAY Dbus bus
    2. Fly from President Donald J. Trump International Airport (PBI) to Rochester (RST)plane plane PBI - RST
    11h 25m
    $181–694

  2. Bus

    1. Take the bus from Port St Lucie to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus bus
    4. Take the bus from Milwaukee to Rochesterbus bus
    36h 44m
    $299–522

  3. Bus, train via Madison

    1. Take the bus from Fort Pierce to Kissimmee -1471 East Osceola Parkwaybus bus
    2. Take the train from Kissimmee Amtrak Station to Chicago Union Stationtrain train
    3. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    4. Take the bus from Madison to Rochesterbus bus
    2d 5h
    $657–1,371

  4. Drive 1,552.8 mi

    1. Drive from Port Saint Lucie to Mayo Cliniccar car 1,552.8 mi
    26h 17m
    $284–410

  5. Bus to President Donald J. Trump International Airport, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the bus from GATLIN BLVD at I-95 P/R LOT to WPB ITC at BAY Dbus bus
    2. Fly from President Donald J. Trump International Airport (PBI) to Minneapolis–Saint Paul International Airport (MSP)plane plane PBI - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    10h
    $262–906

  6. Bus to Orlando, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the bus from Fort Pierce to Kissimmee -1471 East Osceola Parkwaybus bus
    2. Fly from Orlando (MCO) to Minneapolis–Saint Paul International Airport (MSP)plane plane MCO - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    10h 34m
    $286–1,195

  7. Bus to Fort Lauderdale–Hollywood International Airport, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the bus from Fort Pierce to Sheridan Tri-Rail Stationbus bus
    2. Fly from Fort Lauderdale–Hollywood International Airport (FLL) to Minneapolis–Saint Paul International Airport (MSP)plane plane FLL - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    10h 10m
    $553–1,195

  8. Bus to Miami International Airport, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the bus from Fort Pierce to Sheridan Tri-Rail Stationbus bus
    2. Fly from Miami International Airport (MIA) to Minneapolis–Saint Paul International Airport (MSP)plane plane MIA - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    10h 26m
    $405–996

  9. Bus, train

    1. Take the bus from Fort Pierce to Kissimmee -1471 East Osceola Parkwaybus bus
    2. Take the train from Kissimmee Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    4. Take the bus from St. Paul to Rochesterbus bus
    2d 6h
    $740–1,551

Port Saint Lucie to Mayo Clinic by bus, train, and foot

Calendar7Weekly Services
Duration2d 5hAverage Duration
Ticket$657Cheapest Price
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Questions & Answers

Map of how to get from Port Saint Lucie to Mayo Clinic.ExpandLaunch map view
  • Distance: 1,448.6 mi
  • Duration: 11h 25m

What companies run services between Port Saint Lucie, FL, USA and Mayo Clinic, MN, USA?

You can take a vehicle from Port Saint Lucie to Mayo Clinic via Port St Lucie, Atlanta Bus Station, Chicago Bus Station, Milwaukee Intermodal Station, Milwaukee, and Rochester in around 36h 44m.

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