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How to get fromPort Saint Lucie to Panama City Beachby bus (Greyhound), car, taxi, plane, bus (Flixbus, Greyhound), or bus

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There are 7 ways to get from Port Saint Lucie to Panama City Beach by bus (Greyhound), car, taxi, plane, bus (Flixbus, Greyhound), or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Fort Pierce to Kissimmee -1471 East Osceola Parkwaybus bus
    2. Take the bus from Kissimmee -1471 East Osceola Parkway to Tallahassee - FSU - Old St Augustine at Intramural Fieldbus bus
    3. Take the bus from Tallahassee to Panama City Beach Bus Stationbus bus
    12h 8m
    $126–223

  2. Drive 459.6 mi

    cheapest
    1. Drive from Port Saint Lucie to Panama City Beachcar car 459.6 mi
    8h 23m
    $84–122

  3. Taxi to Vero Beach Municipal Airport, fly to Northwest Florida Beaches International Airport

    1. Take the taxi from Port Saint Lucie to Vero Beach Municipal Airport (VRB)taxi taxi
    2. Fly from Vero Beach Municipal Airport (VRB) to Northwest Florida Beaches International Airport (ECP)plane plane VRB - ECP
    7h 49m
    $242–724

  4. Bus via Orlando

    1. Take the bus from Fort Pierce to Kissimmee -1471 East Osceola Parkwaybus bus
    2. Take the bus from Orlando to Tallahasseebus bus
    3. Take the bus from Tallahassee to Panama City Beach Bus Stationbus bus
    12h 57m
    $96–153

  5. Bus to President Donald J. Trump International Airport, fly to Northwest Florida Beaches International Airport

    1. Take the bus from GATLIN BLVD at I-95 P/R LOT to WPB ITC at TRI RAILbus bus
    2. Fly from President Donald J. Trump International Airport (PBI) to Northwest Florida Beaches International Airport (ECP)plane plane PBI - ECP
    7h 24m
    $175–586

  6. Bus to Miami International Airport, fly to Destin–Fort Walton Beach Airport, drive

    1. Take the bus from Fort Pierce to Sheridan Tri-Rail Stationbus bus
    2. Fly from Miami International Airport (MIA) to Destin–Fort Walton Beach Airport (VPS)plane plane MIA - VPS
    3. Drive from Destin–Fort Walton Beach Airport (VPS) to Panama City Beachcar car
    7h 1m
    $98–390

  7. Bus, taxi to Melbourne International Airport, fly to Northwest Florida Beaches International Airport

    1. Take the bus from Fort Pierce to Sebastianbus bus
    2. Take the taxi from Sebastian to Melbourne International Airport (MLB)taxi taxi
    3. Fly from Melbourne International Airport (MLB) to Northwest Florida Beaches International Airport (ECP)plane plane MLB - ECP
    9h 51m
    $210–574

Vero Beach Municipal Airport (VRB) to Northwest Florida Beaches International Airport (ECP) flights

Calendar14Weekly Planes
Duration9h 18mAverage Duration
Ticket$108Cheapest Price
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Questions & Answers

Map of how to get from Port Saint Lucie to Panama City Beach.ExpandLaunch map view
  • Distance: 487.1 mi
  • Duration: 12h 8m

What companies run services between Port Saint Lucie, FL, USA and Panama City Beach, FL, USA?

You can take a bus from Fort Pierce to Panama City Beach via Kissimmee -1471 East Osceola Parkway, Old St Augustine at Intramural Field, Tallahassee, and Panama City Beach Bus Station in around 12h 8m.

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