Rome2Rio

How to get fromPort Saint Lucie to San Diegoby bus, plane, bus (Flixbus, Greyhound, Amtrak), train, car, taxi, or bus (Flixbus, Greyhound)

Find Transport to San Diego

See all options

There are 10 ways to get from Port Saint Lucie to San Diego by bus, plane, bus (Flixbus, Greyhound, Amtrak), train, car, taxi, or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Orlando, fly

    best
    1. Take the bus from Fort Pierce to Kissimmee -1471 East Osceola Parkwaybus bus
    2. Fly from Orlando (MCO) to San Diego International Airport (SAN)plane plane MCO - SAN
    9h 20m
    $254–993

  2. Bus to Miami International Airport, fly

    cheapest
    1. Take the bus from Fort Pierce to Sheridan Tri-Rail Stationbus bus
    2. Fly from Miami International Airport (MIA) to San Diego International Airport (SAN)plane plane MIA - SAN
    9h 5m
    $173–524

  3. Bus

    1. Take the bus from Port St Lucie to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Dallas Bus Stationbus bus
    3. Take the bus from Dallas Bus Station to Los Angeles Union Stationbus bus
    4. Take the bus from Los Angeles to San Diegobus bus
    2d 16h
    $486–891

  4. Bus, train

    1. Take the bus from Fort Pierce to Kissimmee -1471 East Osceola Parkwaybus bus
    2. Take the train from Kissimmee Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Fullerton Amtrak Stationtrain train
    4. Take the train from Fullerton Amtrak Station to San Diegotrain train
    3d 18h
    $1,212–2,811

  5. Drive 2,525.9 mi

    1. Drive from Port Saint Lucie to San Diegocar car 2,525.9 mi
    40h 14m
    $461–666

  6. Bus to Fort Lauderdale–Hollywood International Airport, fly

    1. Take the bus from Fort Pierce to Sheridan Tri-Rail Stationbus bus
    2. Fly from Fort Lauderdale–Hollywood International Airport (FLL) to San Diego International Airport (SAN)plane plane FLL - SAN
    9h 2m
    $321–1,243

  7. Bus to President Donald J. Trump International Airport, fly

    1. Take the bus from GATLIN BLVD at I-95 P/R LOT to WPB ITC at BAY Dbus bus
    2. Fly from President Donald J. Trump International Airport (PBI) to San Diego International Airport (SAN)plane plane PBI - SAN
    10h 20m
    $260–904

  8. Bus to Tampa, fly

    1. Take the bus from Port St Lucie to Tampa Bus Stationbus bus
    2. Fly from Tampa (TPA) to San Diego International Airport (SAN)plane plane TPA - SAN
    11h 26m
    $253–844

  9. Bus, taxi to Melbourne International Airport, fly

    1. Take the bus from Fort Pierce to Sebastianbus bus
    2. Take the taxi from Sebastian to Melbourne International Airport (MLB)taxi taxi
    3. Fly from Melbourne International Airport (MLB) to San Diego International Airport (SAN)plane plane MLB - SAN
    12h 26m
    $280–919

  10. Bus via Deming

    1. Take the bus from Port St Lucie to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Dallas Bus Stationbus bus
    3. Take the bus from Dallas Bus Station to Demingbus bus
    4. Take the bus from Deming, NM to Cross Border Express, San Diegobus bus
    3d
    $479–861

Port Saint Lucie to San Diego by bus and train

Calendar7Weekly Services
Duration3d 18hAverage Duration
Ticket$1,212Cheapest Price
See schedules

Questions & Answers

Map of how to get from Port Saint Lucie to San Diego.ExpandLaunch map view
  • Distance: 2,280.3 mi
  • Duration: 9h 20m

What companies run services between Port Saint Lucie, FL, USA and San Diego, CA, USA?

You can take a vehicle from Port Saint Lucie to San Diego via Port St Lucie, Atlanta Bus Station, Dallas Bus Station, Los Angeles Union Station, and Los Angeles in around 2d 16h.

Airlines
Train operators
Bus operators
Other operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers