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How to get fromPort Saint Lucie to St. Louisby bus, plane, bus (Greyhound, Flixbus), car, bus (Flixbus, Greyhound), or bus (Greyhound)

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There are 8 ways to get from Port Saint Lucie to St. Louis by bus, plane, bus (Greyhound, Flixbus), car, bus (Flixbus, Greyhound), or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Fort Lauderdale–Hollywood International Airport, fly to Lambert–St. Louis International Airport

    best
    1. Take the bus from Fort Pierce to Fort Lauderdale Airportbus bus
    2. Fly from Fort Lauderdale–Hollywood International Airport (FLL) to Lambert–St. Louis International Airport (STL)plane plane FLL - STL
    6h 9m
    $526–1,145

  2. Drive to Orlando Sanford, fly to Midamerica St. Louis Airport

    cheapest
    1. Drive from Port Saint Lucie to Orlando-Sanford-Airport-SFBcar car
    2. Fly from Orlando Sanford (SFB) to Midamerica St. Louis Airport (BLV)plane plane SFB - BLV
    5h 57m
    $135–477

  3. Bus via Orlando

    1. Take the bus from Fort Pierce to Orlando RedCoach Stationbus bus
    2. Take the bus from Orlando RedCoach Station to Atlanta - Civic Center MARTA Stationbus bus
    3. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus
    21h 49m
    $211–425

  4. Drive 1,104.7 mi

    1. Drive from Port Saint Lucie to St. Louiscar car 1,104.7 mi
    18h 9m
    $202–292

  5. Bus to Orlando, fly to Lambert–St. Louis International Airport

    1. Take the bus from Fort Pierce to Orlando RedCoach Stationbus bus
    2. Fly from Orlando (MCO) to Lambert–St. Louis International Airport (STL)plane plane MCO - STL
    6h 18m
    $213–427

  6. Bus to Miami International Airport, fly to Lambert–St. Louis International Airport

    1. Take the bus from Fort Pierce to Miami Airportbus bus
    2. Fly from Miami International Airport (MIA) to Lambert–St. Louis International Airport (STL)plane plane MIA - STL
    6h 43m
    $584–993

  7. Bus

    1. Take the bus from Port St Lucie to Atlanta Bus Stationbus bus FlixBus N2401
    2. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus FlixBus N2521
    22h
    $201–356

  8. Bus via Evansville

    1. Take the bus from Fort Pierce to Sheridan Tri-Rail Stationbus bus
    2. Take the bus from Hollywood Sheridan Trirail Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Evansville Bus Stationbus bus
    4. Take the bus from Evansville Bus Station to St Louis Bus Stationbus bus
    31h 19m
    $215–408

Port Saint Lucie to St. Louis by bus and subway

Calendar7Weekly Services
Duration21h 49mAverage Duration
Ticket$211Cheapest Price
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Questions & Answers

Map of how to get from Port Saint Lucie to St. Louis.ExpandLaunch map view
  • Distance: 1,163.7 mi
  • Duration: 6h 9m

What companies run services between Port Saint Lucie, FL, USA and St. Louis, MO, USA?

You can take a bus from Fort Pierce to St Louis Bus Station via Orlando RedCoach Station, Atlanta - Civic Center MARTA Station, Civic Center Station, Garnett Station, and Atlanta Bus Station in around 21h 49m.

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