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How to get fromPortland Airport (PDX) to Mayo Clinicby plane, bus (Flixbus), train, bus, or car

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There are 6 ways to get from Portland Airport (PDX) to Mayo Clinic by plane, bus (Flixbus), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Rochester

    best
    1. Fly from Portland International Airport (PDX) to Rochester (RST)plane plane PDX - RST
    6h 42m
    $119–538

  2. Bus

    1. Take the bus from Portland Curbside Bus Stop to Pasco Bus Stopbus bus
    2. Take the bus from Pasco Bus Stop to Spokane Stationbus bus
    3. Take the bus from Spokane to Billingsbus bus
    4. Take the bus from Billings to Minneapolisbus bus
    5. Take the bus from Minneapolis to Rochesterbus bus
    38h 38m
    $382–591

  3. Train, bus

    1. Take the train from Portland to St. Paul-Minneapolistrain train Empire Builder
    2. Take the bus from St. Paul to Rochesterbus bus Jefferson Lines 965
    42h 4m
    $581–1,343

  4. Drive 1,763.3 mi

    1. Drive from Portland Airport (PDX) to Mayo Cliniccar car 1,763.3 mi
    27h 49m
    $322–465

  5. Fly to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Portland International Airport (PDX) to Minneapolis–Saint Paul International Airport (MSP)plane plane PDX - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    6h 7m
    $233–488

  6. Fly to La Crosse, bus

    1. Fly from Portland International Airport (PDX) to La Crosse (LSE)plane plane PDX - LSE
    2. Take the bus from Landline - La Crosse Regional Airport to Landline - MSP Terminal-2 Humphreybus bus
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    12h 58m
    $236–692

Portland Airport (PDX) to Mayo Clinic by bus and foot

Calendar7Weekly Services
Duration38h 38mAverage Duration
Ticket$382Cheapest Price
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Questions & Answers

Map of how to get from Portland Airport (PDX) to Mayo Clinic.ExpandLaunch map view
  • Distance: 1,482.3 mi
  • Duration: 6h 42m

What companies run services between Portland Airport (PDX), USA and Mayo Clinic, MN, USA?

Delta, American Airlines, and United Airlines fly from Portland International Airport (PDX) to Rochester (RST) every 4 hours. Alternatively, you can take a bus from Portland International Airport to Mayo Clinic via Portland Flix/Greyhound, Portland Curbside Bus Stop, Pasco Bus Stop, Spokane Station, Spokane, Billings, Minneapolis, and Rochester in around 38h 38m.

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