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How to get fromPortland to Buffaloby plane, bus (Amtrak, Greyhound), bus, train, car, bus (Amtrak, Flixbus), or train (Amtrak)

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There are 7 ways to get from Portland to Buffalo by plane, bus (Amtrak, Greyhound), bus, train, car, bus (Amtrak, Flixbus), or train (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Portland

    best
    1. Fly from Portland (PWM) to Buffalo Niagara International Airport (BUF)plane plane PWM - BUF
    5h
    $125–703

  2. Drive  509.9 mi

    cheapest
    1. Drive from Portland to Buffalocar car 509.9 mi
    10h 22m
    $93–135

  3. Bus

    1. Take the bus from Portland, ME to Boston, MA - South Stationbus bus Portland / ...
    2. Take the bus from Boston to Buffalobus bus Greyhound US0171
    13h
    $101–173

  4. Bus, train

    1. Take the bus from Portland, ME to Boston, MA - South Stationbus bus Portland / ...
    2. Take the train from Boston to Buffalo Depew Stationtrain train Lake Shore Limited
    15h 55m
    $293–603

  5. Bus to Boston Logan Airport, fly

    1. Take the bus from Portland, ME to Logan International Airportbus bus
    2. Fly from Boston Logan Airport (BOS) to Buffalo Niagara International Airport (BUF)plane plane BOS - BUF
    5h 45m
    $119–659

  6. Bus via Ithaca

    1. Take the bus from Portland, ME to Boston, MA - South Stationbus bus
    2. Take the bus from Boston to Ithacabus bus
    3. Take the bus from Ithaca to Buffalobus bus
    15h 29m
    $101–173

  7. Train (Amtrak)

    1. Take the train from Portland to Bostontrain train Downeaster
    2. Take the train from Boston to Buffalo Depew Stationtrain train Lake Shore Limited
    16h 58m
    $341–525

Portland to Buffalo by bus

Calendar7Weekly Buses
Duration13hAverage Duration
Ticket$101Cheapest Price
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Comparing Your Travel Options

Map of how to get from Portland to Buffalo.ExpandLaunch map view
  • Distance: 435.9 mi
  • Duration: 5h

What companies run services between Portland, ME, USA and Buffalo, NY, USA?

Southwest Airlines, United Airlines, and two other airlines fly from Portland (PWM) to Buffalo Niagara International Airport (BUF) hourly. Alternatively, you can take a bus from Portland, ME to Buffalo via Boston, MA - South Station and Boston in around 13h.

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Need to know: Greyhound

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