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How to get fromPortland to Buffaloby plane, bus (Amtrak, Greyhound), train (Amtrak), car, bus, or bus (Amtrak, Flixbus)

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There are 6 ways to get from Portland to Buffalo by plane, bus (Amtrak, Greyhound), train (Amtrak), car, bus, or bus (Amtrak, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Portland

    best
    1. Fly from Portland (PWM) to Buffalo Niagara International Airport (BUF)plane plane PWM - BUF
    4h 56m
    $136–761

  2. Drive  509.9 mi

    cheapest
    1. Drive from Portland to Buffalocar car 509.9 mi
    10h 22m
    $88–126

  3. Bus

    1. Take the bus from Portland, ME to Boston, MA - South Stationbus bus Portland / ...
    2. Take the bus from Boston to Buffalobus bus Greyhound US0171
    13h
    $106–173

  4. Train (Amtrak)

    1. Take the train from Portland to Bostontrain train Downeaster
    2. Take the train from Boston to Buffalo Depew Stationtrain train Lake Shore Limited
    16h 37m
    $339–661

  5. Bus to Boston Logan Airport, fly

    1. Take the bus from Portland, ME to Logan International Airportbus bus
    2. Fly from Boston Logan Airport (BOS) to Buffalo Niagara International Airport (BUF)plane plane BOS - BUF
    5h 32m
    $129–709

  6. Bus via Ithaca

    1. Take the bus from Portland, ME to Boston, MA - South Stationbus bus
    2. Take the bus from Boston to Ithacabus bus
    3. Take the bus from Ithaca to Buffalobus bus
    15h 24m
    $109–233

Portland to Buffalo by bus

Calendar14Weekly Buses
Duration13hAverage Duration
Ticket$106Cheapest Price
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Comparing Your Travel Options

Map of how to get from Portland to Buffalo.ExpandLaunch map view
  • Distance: 435.9 mi
  • Duration: 4h 56m

What companies run services between Portland, ME, USA and Buffalo, NY, USA?

Delta, Southwest Airlines, and three other airlines fly from Portland (PWM) to Buffalo Niagara International Airport (BUF) hourly. Alternatively, you can take a bus from Portland, ME to Buffalo via Boston, MA - South Station and Boston in around 13h.

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Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

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