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How to get fromPortland to Des Moinesby plane, bus (Amtrak, Flixbus, Greyhound), bus, train, or car

Find Transport to Des Moines

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There are 6 ways to get from Portland to Des Moines by plane, bus (Amtrak, Flixbus, Greyhound), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Portland

    best
    1. Fly from Portland (PWM) to Des Moines (DSM)plane plane PWM - DSM
    4h 56m
    $240–1,012

  2. Bus to Boston Logan Airport, fly

    cheapest
    1. Take the bus from Portland, ME to Logan International Airportbus bus
    2. Fly from Boston Logan Airport (BOS) to Des Moines (DSM)plane plane BOS - DSM
    6h 23m
    $220–900

  3. Bus

    1. Take the bus from Portland, ME to Boston, MA - South Stationbus bus
    2. Take the bus from Boston to New York Midtownbus bus
    3. Take the bus from New York Midtown to Chicago Bus Stationbus bus
    4. Take the bus from Chicago Bus Station to Des Moinesbus bus
    32h 33m
    $246–453

  4. Bus, train

    1. Take the bus from Portland, ME to Boston, MA - South Stationbus bus
    2. Take the train from Boston to Chicago Union Stationtrain train
    3. Take the bus from Chicago Bus Station to Des Moinesbus bus
    32h 56m
    $401–843

  5. Drive 1,352.1 mi

    1. Drive from Portland to Des Moinescar car 1,352.1 mi
    24h 30m
    $247–357

  6. Bus, train via Galesburg

    1. Take the bus from Portland, ME to Boston, MA - South Stationbus bus
    2. Take the train from Boston to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Galesburg Amtrak Stationtrain train
    4. Take the bus from Galesburg to Des Moinesbus bus
    34h 48m
    $431–913

Portland to Des Moines by bus

Calendar15Weekly Buses
Duration32h 33mAverage Duration
Ticket$246Cheapest Price
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Questions & Answers

Map of how to get from Portland to Des Moines.ExpandLaunch map view
  • Distance: 1,198.6 mi
  • Duration: 4h 56m

What companies run services between Portland, ME, USA and Des Moines, IA, USA?

Southwest Airlines, Delta, and two other airlines fly from Portland (PWM) to Des Moines (DSM) every 2 hours. Alternatively, you can take a bus from Portland, ME to Des Moines via Boston, MA - South Station, Boston, New York Midtown, and Chicago Bus Station in around 32h 33m.

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Bus operators

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