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How to get fromPortland to Key Westby plane, bus (Amtrak, Flixbus, Greyhound), bus, train, or car

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There are 5 ways to get from Portland to Key West by plane, bus (Amtrak, Flixbus, Greyhound), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Portland

    best
    1. Fly from Portland (PWM) to Key West International Airport (EYW)plane plane PWM - EYW
    5h 45m
    $142–560

  2. Bus to Boston Logan Airport, fly

    cheapest
    1. Take the bus from Portland, ME to Logan International Airportbus bus
    2. Fly from Boston Logan Airport (BOS) to Key West International Airport (EYW)plane plane BOS - EYW
    7h 4m
    $134–482

  3. Bus

    1. Take the bus from Portland, ME to Boston, MA - South Stationbus bus
    2. Take the bus from Boston to Washington Union Stationbus bus
    3. Take the bus from Washington Union Station to Miamibus bus
    4. Take the bus from Miami Airport Station to Big Pine Keybus bus
    5. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    42h 46m
    $315–557

  4. Bus, train

    1. Take the bus from Portland, ME to Boston, MA - South Stationbus bus
    2. Take the train from Boston to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the train from Ny Moynihan Train Hall At Penn Station to Miami Amtrak Stationtrain train
    4. Take the bus from Miami Airport Station to Big Pine Keybus bus
    5. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    43h 13m
    $577–1,826

  5. Drive 1,740.4 mi

    1. Drive from Portland to Key Westcar car 1,740.4 mi
    30h 34m
    $318–459

Portland to Key West by bus, taxi, and foot

Calendar4Weekly Services
Duration42h 46mAverage Duration
Ticket$315Cheapest Price
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Questions & Answers

Map of how to get from Portland to Key West.ExpandLaunch map view
  • Distance: 1,471.5 mi
  • Duration: 5h 45m

What companies run services between Portland, ME, USA and Key West, FL, USA?

Delta, American Airlines, and United Airlines fly from Portland (PWM) to Key West International Airport (EYW) 3 times a day. Alternatively, you can take a bus from Portland, ME to N Roosevelt & 3rd Street via Boston, MA - South Station, Boston, Washington Union Station, Miami, Miami Airport Station, Big Pine Key, and Big Pine Key - CVS / MM30 in around 42h 46m.

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