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How to get fromPortland to Knoxvilleby plane, bus, train, car, bus (Amtrak, Greyhound), or bus (Amtrak, Flixbus)

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There are 8 ways to get from Portland to Knoxville by plane, bus, train, car, bus (Amtrak, Greyhound), or bus (Amtrak, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Portland to Mcghee Tyson Airport

    best
    1. Fly from Portland (PWM) to Mcghee Tyson Airport (TYS)plane plane PWM - TYS
    4h 32m
    $250–997

  2. Bus #2

    cheapest
    1. Take the bus from Portland, ME to Boston, MA - South Stationbus bus
    2. Take the bus from Boston to NYC Downtownbus bus
    3. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    24h 55m
    $150–218

  3. Bus, train

    1. Take the bus from Portland, ME to Boston, MA - South Stationbus bus
    2. Take the train from Boston to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    20h 16m
    $209–956

  4. Drive 1,008.8 mi

    1. Drive from Portland to Knoxvillecar car 1,008.8 mi
    17h 40m
    $185–266

  5. Fly Portland to Nashville, drive

    1. Fly from Portland (PWM) to Nashville (BNA)plane plane PWM - BNA
    2. Drive from Nashville-Airport-BNA to Knoxvillecar car
    5h 29m
    $161–655

  6. Bus to Boston Logan Airport, fly to Mcghee Tyson Airport

    1. Take the bus from Portland, ME to Logan International Airportbus bus
    2. Fly from Boston Logan Airport (BOS) to Mcghee Tyson Airport (TYS)plane plane BOS - TYS
    5h 46m
    $228–849

  7. Bus via New York

    1. Take the bus from Portland, ME to Boston, MA - South Stationbus bus
    2. Take the bus from Boston to Port Authority Bus Terminalbus bus
    3. Take the bus from New York to Knoxvillebus bus Nyc
    20h 47m
    $234–361

  8. Bus

    1. Take the bus from Portland, ME to Boston, MA - South Stationbus bus
    2. Take the bus from Boston to NYC Downtownbus bus
    3. Take the bus from New York to Knoxvillebus bus Nyc
    20h 56m
    $231–353

Portland (PWM) to Mcghee Tyson Airport (TYS) flights

Calendar71Weekly Planes
Duration5h 19mAverage Duration
Ticket$195Cheapest Price
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Questions & Answers

Map of how to get from Portland to Knoxville.ExpandLaunch map view
  • Distance: 917.5 mi
  • Duration: 4h 32m

What companies run services between Portland, ME, USA and Knoxville, TN, USA?

Southwest Airlines, Delta, and two other airlines fly from Portland (PWM) to Mcghee Tyson Airport (TYS) every 3 hours. Alternatively, you can take a bus from Portland, ME to Knoxville via Boston, MA - South Station, Boston, Port Authority Bus Terminal, 42 St-Bryant Park, East Broadway, New York, and Knoxville in around 20h 47m.

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