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How to get fromPortland to La Crosseby plane, bus, train, bus (Amtrak, Flixbus, Greyhound), or car

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There are 7 ways to get from Portland to La Crosse by plane, bus, train, bus (Amtrak, Flixbus, Greyhound), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to La Crosse

    best
    1. Fly from Portland (PWM) to La Crosse (LSE)plane plane PWM - LSE
    5h 53m
    $146–597

  2. Bus, train

    1. Take the bus from Portland, ME to Boston, MA - South Stationbus bus
    2. Take the train from Boston to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to La Crosse Amtrak Stationtrain train
    31h 16m
    $426–933

  3. Bus

    1. Take the bus from Portland, ME to Boston, MA - South Stationbus bus
    2. Take the bus from Boston to New York Midtownbus bus
    3. Take the bus from New York Midtown to Chicago Bus Stationbus bus
    4. Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus bus
    5. Take the bus from Milwaukee to La Crossebus bus
    31h 51m
    $254–444

  4. Drive 1,317.8 mi

    1. Drive from Portland to La Crossecar car 1,317.8 mi
    23h 56m
    $241–348

  5. Fly to Minneapolis–Saint Paul International Airport, train

    1. Fly from Portland (PWM) to Minneapolis–Saint Paul International Airport (MSP)plane plane PWM - MSP
    2. Take the train from St. Paul-Minneapolis to La Crosse Amtrak Stationtrain train
    7h 28m
    $201–801

  6. Fly to Dane County Regional Airport-Truax Field, bus

    1. Fly from Portland (PWM) to Dane County Regional Airport-Truax Field (MSN)plane plane PWM - MSN
    2. Take the bus from Madison to La Crossebus bus
    9h 25m
    $215–886

  7. Fly to Rochester, bus

    1. Fly from Portland (PWM) to Rochester (RST)plane plane PWM - RST
    2. Take the bus from Rochester to La Crossebus bus
    9h 18m
    $160–667

Portland to La Crosse by bus and train

Calendar7Weekly Services
Duration31h 16mAverage Duration
Ticket$426Cheapest Price
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Questions & Answers

Map of how to get from Portland to La Crosse.ExpandLaunch map view
  • Distance: 1,050.4 mi
  • Duration: 5h 53m

What companies run services between Portland, ME, USA and La Crosse, WI, USA?

American Airlines and United Airlines fly from Portland (PWM) to La Crosse (LSE) every 4 hours. Alternatively, you can take a bus from Portland, ME to La Crosse via Boston, MA - South Station, Boston, New York Midtown, Chicago Bus Station, Milwaukee Intermodal Station, and Milwaukee in around 31h 51m.

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