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How to get fromPortland to Lexingtonby plane, car, bus (Amtrak, Greyhound), bus, train, or bus (Flixbus, Greyhound)

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There are 9 ways to get from Portland to Lexington by plane, car, bus (Amtrak, Greyhound), bus, train, or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Portland to Louisville International Airport, drive

    best
    1. Fly from Portland (PWM) to Louisville International Airport (SDF)plane plane PWM - SDF
    2. Drive from Louisville-Airport-SDF to Lexingtoncar car
    5h 49m
    $349–1,114

  2. Bus to Boston Logan Airport, fly to Louisville International Airport, drive

    cheapest
    1. Take the bus from Portland, ME to Logan International Airportbus bus
    2. Fly from Boston Logan Airport (BOS) to Louisville International Airport (SDF)plane plane BOS - SDF
    3. Drive from Louisville-Airport-SDF to Lexingtoncar car
    7h 8m
    $157–650

  3. Bus

    1. Take the bus from Portland, ME to Boston, MA - South Stationbus bus
    2. Take the bus from Boston to Cleveland Bus Stationbus bus
    3. Take the bus from Cleveland Bus Station to Wilson & Ferrell Shell Station - Columbusbus bus
    4. Take the bus from N Wilson Rd & Ferrell Pl - Columbus to Cincinnati, OHbus bus
    5. Take the bus from Cincinnati Bus Station to Lexington Bus Stopbus bus
    25h 57m
    $193–403

  4. Bus, train

    1. Take the bus from Portland, ME to Boston, MA - South Stationbus bus
    2. Take the train from Boston to Toledotrain train
    3. Take the bus from Toledo Bus Stop to Lexington Bus Stopbus bus
    28h 35m
    $343–715

  5. Drive 1,001.1 mi

    1. Drive from Portland to Lexingtoncar car 1,001.1 mi
    17h 44m
    $183–264

  6. Fly Portland to Blue Grass Airport

    1. Fly from Portland (PWM) to Blue Grass Airport (LEX)plane plane PWM - LEX
    7h 2m
    $226–1,061

  7. Fly Portland to Covington, bus

    1. Fly from Portland (PWM) to Covington (CVG)plane plane PWM - CVG
    2. Take the bus from Cincinnati Bus Station to Lexington Bus Stopbus bus
    7h 34m
    $188–1,452

  8. Bus via New York

    1. Take the bus from City of Portland to New York Midtownbus bus
    2. Take the bus from New York Midtown to Dayton Trotwood Bus Stationbus bus
    3. Take the bus from Dayton Trotwood Bus Station to Lexington Bus Stopbus bus
    28h 34m
    $201–342

  9. Train, bus

    1. Take the train from Portland to Bostontrain train
    2. Take the train from Boston to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the train from Ny Moynihan Train Hall At Penn Station to Indianapolistrain train
    4. Take the bus from Indianapolis Union Station to Lexington Bus Stopbus bus
    36h 40m

Portland to Lexington by bus and taxi

Calendar4Weekly Services
Duration28h 34mAverage Duration
Ticket$201Cheapest Price
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Questions & Answers

Map of how to get from Portland to Lexington.ExpandLaunch map view
  • Distance: 967.3 mi
  • Duration: 5h 49m

What companies run services between Portland, ME, USA and Lexington, KY, USA?

You can take a bus from Portland, ME to Lexington via Boston, MA - South Station, Boston, Cleveland Bus Station, N Wilson Rd & Ferrell Pl - Columbus, Cincinnati, OH, Cincinnati Bus Station, and Lexington Bus Stop in around 25h 57m. Alternatively, Delta, American Airlines, and United Airlines fly from Portland (PWM) to Blue Grass Airport (LEX) every 2 hours.

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