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How to get fromPortland to Louisvilleby plane, bus (Amtrak, Greyhound), bus, train, car, or bus (Flixbus)

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There are 9 ways to get from Portland to Louisville by plane, bus (Amtrak, Greyhound), bus, train, car, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Portland to Louisville International Airport

    best
    1. Fly from Portland (PWM) to Louisville International Airport (SDF)plane plane PWM - SDF
    5h 31m
    $164–773

  2. Bus to Boston Logan Airport, fly to Louisville International Airport

    cheapest
    1. Take the bus from Portland, ME to Logan International Airportbus bus
    2. Fly from Boston Logan Airport (BOS) to Louisville International Airport (SDF)plane plane BOS - SDF
    6h 50m
    $144–682

  3. Bus via Brook Park

    1. Take the bus from Portland, ME to Boston, MA - South Stationbus bus
    2. Take the bus from Boston to Cleveland Bus Stationbus bus
    3. Take the bus from Cleveland Bus Station to Wilson & Ferrell Shell Station - Columbusbus bus
    4. Take the bus from N Wilson Rd & Ferrell Pl - Columbus to Louisville, KY Bus Stationbus bus
    25h 40m
    $162–343

  4. Bus, train

    1. Take the bus from Portland, ME to Boston, MA - South Stationbus bus
    2. Take the train from Boston to Toledotrain train
    3. Take the bus from Toledo to Indianapolis, INbus bus
    4. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    28h 48m
    $314–703

  5. Drive 1,036 mi

    1. Drive from Portland to Louisvillecar car 1,036 mi
    18h 35m
    $190–274

  6. Fly Portland to Blue Grass Airport, drive

    1. Fly from Portland (PWM) to Blue Grass Airport (LEX)plane plane PWM - LEX
    2. Drive from Lexington-Airport-LEX to Louisvillecar car
    5h 57m
    $237–1,097

  7. Fly Portland to Covington, bus

    1. Fly from Portland (PWM) to Covington (CVG)plane plane PWM - CVG
    2. Take the bus from Cincinnati - Downtown to Louisville, KY Bus Stationbus bus
    6h 20m
    $155–1,407

  8. Bus

    1. Take the bus from City of Portland to New York Midtownbus bus
    2. Take the bus from New York Midtown to Cincinnatibus bus
    3. Take the bus from Cincinnati - Downtown to Louisville, KY Bus Stationbus bus
    27h 33m
    $185–338

  9. Train, bus (Amtrak)

    1. Take the train from Portland to Bostontrain train
    2. Take the train from Boston to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the train from Ny Moynihan Train Hall At Penn Station to Indianapolistrain train
    4. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    35h 3m
    $412–1,524

Portland to Louisville by bus

Calendar7Weekly Buses
Duration25h 40mAverage Duration
Ticket$162Cheapest Price
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Questions & Answers

Map of how to get from Portland to Louisville.ExpandLaunch map view
  • Distance: 894 mi
  • Duration: 5h 31m

What companies run services between Portland, ME, USA and Louisville, KY, USA?

Southwest Airlines, United Airlines, and two other airlines fly from Portland (PWM) to Louisville International Airport (SDF) 5 times a day. Alternatively, you can take a bus from Portland, ME to Louisville, KY Bus Station via Boston, MA - South Station, Boston, Cleveland Bus Station, and N Wilson Rd & Ferrell Pl - Columbus in around 25h 40m.

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