There are 4 ways to get from Portland to Natick by bus, train, train (Amtrak), car, or bus (Amtrak)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus, train
best- Take the bus from City of Portland to Bostonbus FlixBus N2615
- Take the train from South Station to Natick Centertrain Framingham/Worcester Line
3h 20m$20–37Train (Amtrak)
- Take the train from Portland to Bostontrain Downeaster
4h$69–109Drive 120.4 mi
- Drive from Portland to Natickcar 120.4 mi
2h 23m$22–32Bus
- Take the bus from Portland, ME to Boston, MA - South Stationbus Portland / ...
- Take the bus from South Station - Bus Terminal Gates 4-6 to Natick Center - South Ave opp Adams Stbus Worcester Line Shuttle
3h 38m$22–48
Portland to Natick by bus and train
Comparing Your Travel Options
The cheapest way to get from Portland to Natick is to drive which costs $22 - $35 and takes 2h 23m.
The fastest way to get from Portland to Natick is to drive which takes 2h 23m and costs $22 - $35.
No, there is no direct bus from Portland to Natick. However, there are services departing from Portland, ME and arriving at Natick Center - South Ave opp Adams St via South Station - Bus Terminal Gates 4-6. The journey, including transfers, takes approximately 3h 38m.
No, there is no direct train from Portland to Natick. However, there are services departing from Portland and arriving at Natick Center via North Station and Back Bay. The journey, including transfers, takes approximately 4h.
The distance between Portland and Natick is 126 miles. The road distance is 121.2 miles.
The best way to get from Portland to Natick without a car is to bus and train which takes 3h 20m and costs $20 - $40.
It takes approximately 3h 20m to get from Portland to Natick, including transfers.
Portland to Natick bus services, operated by Concord Coach Lines, depart from Portland, ME station.
Portland to Natick train services, operated by Amtrak, depart from Portland station.
The best way to get from Portland to Natick is to train which takes 4h and costs $65 - $110. Alternatively, you can bus, which costs $22 - $50 and takes 3h 38m.
What companies run services between Portland, ME, USA and Natick, MA, USA?
Amtrak operates a train from Portland to Boston every 4 hours. Tickets cost $60–100 and the journey takes 2h 32m. Alternatively, you can take a bus from Portland, ME to Natick Center - South Ave opp Adams St via Boston, MA - South Station and South Station - Bus Terminal Gates 4-6 in around 3h 38m.
Train from South Station to Natick Center
- Ave. Duration
- 44 min
- Frequency
- Hourly
- Estimated price
- $3–9
- Website
- Massachusetts Bay Transportation Authority
- Website
- MBTA: World Cup 2026
- Adult
- $3–9
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Portland to Boston
- Ave. Duration
- 2h 32m
- Frequency
- Every 4 hours
- Estimated price
- $60–100
- Website
- Amtrak
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from City of Portland to Boston
- Ave. Duration
- 1h 56m
- Frequency
- 6 times a week
- Estimated price
- $17–25
- Schedules at
- Flixbus USA
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from City of Portland to Boston
- Ave. Duration
- 2h 30m
- Frequency
- Once daily
- Estimated price
- $19–29
- Website
- Greyhound
- Phone
- +1 800 639 3317
- [email protected]
- Website
- Concord Coach Lines
Bus from Portland, ME to Boston, MA - South Station
- Ave. Duration
- 1h 55m
- Frequency
- Hourly
- Estimated price
- $23–35
- Website
- Concord Coach Lines
Rome2Rio's guide to Amtrak Thruway
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Bus from Portland, ME to Boston, MA - South Station
- Ave. Duration
- 1h 55m
- Frequency
- Hourly
- Estimated price
- $21–45
- Website
- Amtrak
- Adult
- $21–45
Bus from South Station - Bus Terminal Gates 4-6 to Natick Center - South Ave opp Adams St
- Ave. Duration
- 43 min
- Frequency
- 3 times a day
- Estimated price
- $1–5
- Website
- Massachusetts Bay Transportation Authority
- Website
- MBTA: World Cup 2026
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Booking & Getting There
Portland to Natick bus services, operated by Concord Coach Lines, arrive at Boston, MA - South Station.
Portland to Natick train services, operated by Amtrak, arrive at Boston station.
Yes, the driving distance between Portland to Natick is 121 miles. It takes approximately 2h 23m to drive from Portland to Natick.
There are 479+ hotels available in Natick.