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How to get fromPortland to Saint Charlesby plane, bus, train, car, bus (Amtrak, Greyhound, Flixbus), or bus (Amtrak, Flixbus, Greyhound)

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There are 7 ways to get from Portland to Saint Charles by plane, bus, train, car, bus (Amtrak, Greyhound, Flixbus), or bus (Amtrak, Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Portland

    best
    1. Fly from Portland (PWM) to Lambert–St. Louis International Airport (STL)plane plane PWM - STL
    5h 47m
    $184–818

  2. Bus, train

    1. Take the bus from Portland, ME to Boston, MA - South Stationbus bus
    2. Take the train from Boston to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Louistrain train
    32h 28m
    $435–937

  3. Train, bus

    1. Take the train from Portland to Bostontrain train
    2. Take the train from Boston to Newark Penn Stationtrain train
    3. Take the bus from Newark Penn Station to St Louis Bus Stationbus bus
    32h 59m
    $239–1,122

  4. Drive 1,263.6 mi

    1. Drive from Portland to Saint Charlescar car 1,263.6 mi
    22h 24m
    $231–334

  5. Bus to Boston Logan Airport, fly

    1. Take the bus from Portland, ME to Logan International Airportbus bus
    2. Fly from Boston Logan Airport (BOS) to Lambert–St. Louis International Airport (STL)plane plane BOS - STL
    6h 59m
    $387–883

  6. Bus

    1. Take the bus from Portland, ME to Boston, MA - South Stationbus bus
    2. Take the bus from Boston to Newark Penn Stationbus bus
    3. Take the bus from Newark Penn Station to St Louis Bus Stationbus bus
    33h 43m
    $198–410

  7. Bus via Boston

    1. Take the bus from Portland, ME to Boston, MA - South Stationbus bus
    2. Take the bus from Cambridge to Newark Penn Stationbus bus
    3. Take the bus from Newark Penn Station to St Louis Bus Stationbus bus
    34h 46m
    $213–415

Portland to Saint Charles by bus and train

Calendar7Weekly Services
Duration32h 28mAverage Duration
Ticket$435Cheapest Price
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Questions & Answers

Map of how to get from Portland to Saint Charles.ExpandLaunch map view
  • Distance: 1,107.2 mi
  • Duration: 5h 47m

What companies run services between Portland, ME, USA and Saint Charles, MO, USA?

Southwest Airlines, Delta, and United Airlines fly from Portland (PWM) to Lambert–St. Louis International Airport (STL) every 3 hours. Alternatively, you can take a bus from Portland, ME to 4375 Rider Trail North Sb via Boston, MA - South Station, Boston, Newark Penn Station, St Louis Bus Station, Civic Center Transit Center, and North Hanley Transit Center in around 33h 43m.

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