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How to get fromPortland to St. Louisby plane, bus, train, bus (Amtrak, Greyhound), car, or bus (Amtrak, Greyhound, Flixbus)

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There are 6 ways to get from Portland to St. Louis by plane, bus, train, bus (Amtrak, Greyhound), car, or bus (Amtrak, Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Portland

    best
    1. Fly from Portland (PWM) to Lambert–St. Louis International Airport (STL)plane plane PWM - STL
    5h 23m
    $187–825

  2. Bus, train

    1. Take the bus from Portland, ME to Boston, MA - South Stationbus bus
    2. Take the train from Boston to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Louistrain train
    31h 3m
    $441–933

  3. Bus

    1. Take the bus from Portland, ME to Boston, MA - South Stationbus bus
    2. Take the bus from South Station to Port Authority Bus Terminalbus bus
    3. Take the bus from Port Authority Bus Terminal to St Louis Bus Stationbus bus
    31h 30m
    $221–483

  4. Drive 1,249.4 mi

    1. Drive from Portland to St. Louiscar car 1,249.4 mi
    22h 7m
    $228–330

  5. Bus to Boston Logan Airport, fly

    1. Take the bus from Portland, ME to Logan International Airportbus bus
    2. Fly from Boston Logan Airport (BOS) to Lambert–St. Louis International Airport (STL)plane plane BOS - STL
    6h 34m
    $386–882

  6. Bus via Newark

    1. Take the bus from Portland, ME to Boston, MA - South Stationbus bus
    2. Take the bus from Boston to Newark Penn Stationbus bus
    3. Take the bus from Newark Penn Station to St Louis Bus Stationbus bus
    31h 31m
    $211–423

Portland to St. Louis by bus and train

Calendar7Weekly Services
Duration31h 3mAverage Duration
Ticket$441Cheapest Price
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Questions & Answers

Map of how to get from Portland to St. Louis.ExpandLaunch map view
  • Distance: 1,107.1 mi
  • Duration: 5h 23m

What companies run services between Portland, ME, USA and St. Louis, MO, USA?

Southwest Airlines, Delta, and United Airlines fly from Portland (PWM) to Lambert–St. Louis International Airport (STL) every 3 hours. Alternatively, you can take a bus from Portland, ME to St Louis Bus Station via Boston, MA - South Station, South Station, and Port Authority Bus Terminal in around 31h 30m.

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