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How to get fromPortland to Winston-Salemby plane, bus (Amtrak, Flixbus), bus, train, car, or bus (Amtrak, Greyhound)

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There are 7 ways to get from Portland to Winston-Salem by plane, bus (Amtrak, Flixbus), bus, train, car, or bus (Amtrak, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Piedmont Triad International Airport

    best
    1. Fly from Portland (PWM) to Piedmont Triad International Airport (GSO)plane plane PWM - GSO
    5h 12m
    $174–801

  2. Bus via New York

    cheapest
    1. Take the bus from Portland, ME to Boston, MA - South Stationbus bus
    2. Take the bus from Boston to NYC Downtownbus bus
    3. Take the bus from New York, NY to Winston-Salem, NCbus bus Nyc
    18h 55m
    $131–213

  3. Bus, train

    1. Take the bus from Portland, ME to Boston, MA - South Stationbus bus
    2. Take the train from Boston to Lynchburgtrain train
    3. Take the train from Lynchburg to Greensborotrain train
    4. Take the bus from Greensboro Bus Stop to Winston Salem(Trans Center)bus bus
    20h 16m
    $260–546

  4. Drive 840.1 mi

    1. Drive from Portland to Winston-Salemcar car 840.1 mi
    15h 48m
    $154–222

  5. Fly to Charlotte Douglas International Airport, bus

    1. Fly from Portland (PWM) to Charlotte Douglas International Airport (CLT)plane plane PWM - CLT
    2. Take the bus from Charlotte Bus Station to Winston Salem(Trans Center)bus bus
    5h 41m
    $163–789

  6. Fly to Raleigh-Durham International Airport, bus

    1. Fly from Portland (PWM) to Raleigh-Durham International Airport (RDU)plane plane PWM - RDU
    2. Take the bus from Durham to Winston Salem(Trans Center)bus bus
    6h 16m
    $173–659

  7. Bus

    1. Take the bus from Portland, ME to Boston, MA - South Stationbus bus
    2. Take the bus from Boston to Port Authority Bus Terminalbus bus
    3. Take the bus from Port Authority Bus Terminal to Winston Salem(Trans Center)bus bus
    23h 23m
    $146–298

Portland to Winston-Salem by bus and train

Calendar5Weekly Services
Duration20h 16mAverage Duration
Ticket$260Cheapest Price
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Questions & Answers

Map of how to get from Portland to Winston-Salem.ExpandLaunch map view
  • Distance: 751.6 mi
  • Duration: 5h 12m

What companies run services between Portland, ME, USA and Winston-Salem, NC, USA?

United Airlines, American Airlines, and Delta fly from Portland (PWM) to Piedmont Triad International Airport (GSO) hourly. Alternatively, you can take a bus from Portland, ME to Winston-Salem, NC via Boston, MA - South Station, Boston, NYC Downtown, and New York, NY in around 18h 55m.

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