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How to get fromPortsmouth to Key Westby bus, plane, bus (Flixbus, Greyhound), train, or car

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There are 8 ways to get from Portsmouth to Key West by bus, plane, bus (Flixbus, Greyhound), train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Boston Logan Airport, fly

    best
    1. Take the bus from Portsmouth to Bostonbus bus
    2. Fly from Boston Logan Airport (BOS) to Key West International Airport (EYW)plane plane BOS - EYW
    6h 48m
    $126–480

  2. Bus, train to Theodore Francis Green State Airport, fly

    cheapest
    1. Take the bus from Portsmouth Bus Stop to Bostonbus bus
    2. Take the train from South Station to TF Green Airporttrain train
    3. Fly from Theodore Francis Green State Airport (PVD) to Key West International Airport (EYW)plane plane PVD - EYW
    10h 7m
    $124–465

  3. Bus

    1. Take the bus from Portsmouth Bus Stop to Bostonbus bus
    2. Take the bus from Boston to Washington Union Stationbus bus
    3. Take the bus from Washington Union Station to Miamibus bus
    4. Take the bus from Miami Airport Station to Big Pine Keybus bus
    5. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    41h 56m
    $282–505

  4. Bus, train

    1. Take the bus from Portsmouth Bus Stop to New York Midtownbus bus
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Miami Amtrak Stationtrain train
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    4. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    42h 54m
    $526–1,093

  5. Drive 1,690.7 mi

    1. Drive from Portsmouth to Key Westcar car 1,690.7 mi
    29h 46m
    $309–446

  6. Bus to Portland, fly

    1. Take the bus from Portsmouth Bus Stop to City of Portlandbus bus
    2. Fly from Portland (PWM) to Key West International Airport (EYW)plane plane PWM - EYW
    8h 36m
    $151–581

  7. Bus, bus to Manchester Airport, fly

    1. Take the bus from Portsmouth Bus Stop to Bostonbus bus
    2. Take the bus from Boston to Boston Manchester Airportbus bus
    3. Fly from Manchester Airport (MHT) to Key West International Airport (EYW)plane plane MHT - EYW
    10h 20m
    $147–594

  8. Fly from Portsmouth International Airport At Pease

    1. Fly from Portsmouth International Airport At Pease (PSM) to Key West International Airport (EYW)plane plane PSM - EYW
    18h 59m
    $182–864

Portsmouth to Key West by bus, taxi, and foot

Calendar8Weekly Services
Duration41h 56mAverage Duration
Ticket$282Cheapest Price
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Questions & Answers

Map of how to get from Portsmouth to Key West.ExpandLaunch map view
  • Distance: 1,433.9 mi
  • Duration: 6h 48m

What companies run services between Portsmouth, NH, USA and Key West, FL, USA?

You can take a bus from Portsmouth Bus Stop to N Roosevelt & 3rd Street via Boston, Washington Union Station, Miami, Miami Airport Station, Big Pine Key, and Big Pine Key - CVS / MM30 in around 41h 56m. Alternatively, Breeze Airways flies from Portsmouth International Airport At Pease (PSM) to Key West International Airport (EYW) 3 times a week.

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