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How to get fromPoughkeepsie to Buffalo Depew Stationby train (Amtrak), car, train, or plane

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There are 7 ways to get from Poughkeepsie to Buffalo Depew Station by train (Amtrak), car, train, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train

    best
    1. Take the train from Poughkeepsie Amtrak Station to Buffalo Depew Stationtrain train Maple Leaf / ...
    6h 34m
    $95–260

  2. Drive 323.9 mi

    cheapest
    1. Drive from Poughkeepsie to Buffalo Depew Stationcar car 323.9 mi
    6h 31m
    $60–86

  3. Train to Laguardia Airport, fly to Buffalo Niagara International Airport

    1. Take the train from Poughkeepsie to 125th Street - Harlemtrain train
    2. Fly from Laguardia Airport (LGA) to Buffalo Niagara International Airport (BUF)plane plane LGA - BUF
    4h 49m
    $127–700

  4. Train to John F. Kennedy International Airport, fly to Buffalo Niagara International Airport

    1. Take the train from Poughkeepsie to Grand Central Terminaltrain train
    2. Fly from John F. Kennedy International Airport (JFK) to Buffalo Niagara International Airport (BUF)plane plane JFK - BUF
    4h 59m
    $119–541

  5. Train to Newark Liberty International Airport, fly to Buffalo Niagara International Airport

    1. Take the train from Poughkeepsie Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Fly from Newark Liberty International Airport (EWR) to Buffalo Niagara International Airport (BUF)plane plane EWR - BUF
    4h 43m
    $130–579

  6. Train to Laguardia Airport, fly to Rochester, train

    1. Take the train from Poughkeepsie to 125th Street - Harlemtrain train
    2. Fly from Laguardia Airport (LGA) to Rochester (ROC)plane plane LGA - ROC
    3. Take the train from Rochester to Buffalo Depew Stationtrain train
    6h 52m
    $145–818

  7. Train to Newark Liberty International Airport, fly to Rochester, train

    1. Take the train from Poughkeepsie Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Fly from Newark Liberty International Airport (EWR) to Rochester (ROC)plane plane EWR - ROC
    3. Take the train from Rochester to Buffalo Depew Stationtrain train
    6h 47m
    $548–1,857

Poughkeepsie to Buffalo Depew Station by train

Calendar35Weekly Trains
Duration6h 34mAverage Duration
Ticket$95Cheapest Price
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Questions & Answers

Map of how to get from Poughkeepsie to Buffalo Depew Station.ExpandLaunch map view
  • Distance: 357.7 mi
  • Duration: 6h 34m

What companies run services between Poughkeepsie, NY, USA and Buffalo Depew Station, NY, USA?

Amtrak operates a train from Poughkeepsie Amtrak Station to Buffalo Depew Station 4 times a day. Tickets cost $110–240 and the journey takes 6h 34m. VIA Rail also services this route once daily.

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