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How to get fromPoughkeepsie to Florenceby train (Amtrak), bus, car, train, or plane

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There are 12 ways to get from Poughkeepsie to Florence by train (Amtrak), bus, car, train, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train (Amtrak)

    best
    1. Take the train from Poughkeepsie Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train Empire Service / ...
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Florence Stationtrain train Palmetto / ...
    17h 11m
    $179–401

  2. Bus

    cheapest
    1. Take the bus from Newburgh ShortLine Transportation Center to Broadway & Chambers Stbus bus ShortLine Hudson
    2. Take the bus from New York, NY to Florence, SCbus bus Nyc
    17h 42m
    $113–191

  3. Drive  694.9 mi

    1. Drive from Poughkeepsie to Florencecar car 694.9 mi
    12h 28m
    $127–184

  4. Train to Laguardia Airport, fly to Myrtle Beach, bus, train

    1. Take the train from Poughkeepsie to 125th Street - Harlemtrain train
    2. Fly from Laguardia Airport (LGA) to Myrtle Beach (MYR)plane plane LGA - MYR
    3. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    4. Take the train from Charleston Amtrak Station to Florence Stationtrain train
    11h 5m
    $146–570

  5. Train, bus

    1. Take the train from Poughkeepsie to 125th Street - Harlemtrain train
    2. Take the bus from New York City Chinatown to Fayetteville Bus Stationbus bus
    3. Take the bus from Fayetteville Bus Station to Florence Bus Stationbus bus
    17h 50m
    $119–198

  6. Train to Newark Liberty International Airport, fly to Myrtle Beach, bus, train

    1. Take the train from Poughkeepsie Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Fly from Newark Liberty International Airport (EWR) to Myrtle Beach (MYR)plane plane EWR - MYR
    3. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    4. Take the train from Charleston Amtrak Station to Florence Stationtrain train
    11h 11m
    $440–863

  7. Train to Laguardia Airport, fly to Raleigh-Durham International Airport, train

    1. Take the train from Poughkeepsie to 125th Street - Harlemtrain train
    2. Fly from Laguardia Airport (LGA) to Raleigh-Durham International Airport (RDU)plane plane LGA - RDU
    3. Take the train from Raleigh Union Station to Selma Stationtrain train
    4. Take the train from Selma Station to Florence Stationtrain train
    11h 44m
    $181–571

  8. Train to Newark Liberty International Airport, fly to Raleigh-Durham International Airport, train

    1. Take the train from Poughkeepsie Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Fly from Newark Liberty International Airport (EWR) to Raleigh-Durham International Airport (RDU)plane plane EWR - RDU
    3. Take the train from Raleigh Union Station to Selma Stationtrain train
    4. Take the train from Selma Station to Florence Stationtrain train
    11h 42m
    $230–964

  9. Train to Westchester County Airport, fly to Charlotte Douglas International Airport, bus

    1. Take the train from Poughkeepsie to 125th Street - Harlemtrain train
    2. Fly from Westchester County Airport (HPN) to Charlotte Douglas International Airport (CLT)plane plane HPN - CLT
    3. Take the bus from Charlotte Bus Station to Camdenbus bus
    4. Take the bus from Camden to Florence Bus Stationbus bus
    12h 24m
    $202–983

  10. Fly Stewart International Airport to Myrtle Beach, bus, train

    1. Fly from Stewart International Airport (SWF) to Myrtle Beach (MYR)plane plane SWF - MYR
    2. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    3. Take the train from Charleston Amtrak Station to Florence Stationtrain train
    10h 58m
    $119–453

  11. Train to Westchester County Airport, fly to Myrtle Beach, bus, train

    1. Take the train from Poughkeepsie to 125th Street - Harlemtrain train
    2. Fly from Westchester County Airport (HPN) to Myrtle Beach (MYR)plane plane HPN - MYR
    3. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    4. Take the train from Charleston Amtrak Station to Florence Stationtrain train
    13h 9m
    $179–739

  12. Train, train to Tweed-New Haven Airport, fly to Myrtle Beach, bus

    1. Take the train from Poughkeepsie to 125th Street - Harlemtrain train
    2. Take the train from 125th Street - Harlem to New Haventrain train
    3. Fly from Tweed-New Haven Airport (HVN) to Myrtle Beach (MYR)plane plane HVN - MYR
    4. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    5. Take the train from Charleston Amtrak Station to Florence Stationtrain train
    14h 14m
    $249–642

Poughkeepsie to Florence by train (Amtrak)

Calendar14Weekly Trains
Duration17h 11mAverage Duration
Ticket$179Cheapest Price
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Comparing Your Travel Options

Map of how to get from Poughkeepsie to Florence.ExpandLaunch map view
  • Distance: 704.4 mi
  • Duration: 17h 11m

What companies run services between Poughkeepsie, NY, USA and Florence, SC, USA?

You can take a train from Poughkeepsie Amtrak Station to Florence Station via Ny Moynihan Train Hall At Penn Station in around 17h 11m. Alternatively, you can take a train from Poughkeepsie to Florence, SC via Beacon, Beacon Station, Newburgh ShortLine Transportation Center, Broadway & Chambers St, Broadway/Warren St, Madison St/Pike St, and New York, NY in around 17h 42m.

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