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How to get fromPoughkeepsie to Florence Stationby train, bus, train (Amtrak), car, plane, or bus (Greyhound)

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There are 12 ways to get from Poughkeepsie to Florence Station by train, bus, train (Amtrak), car, plane, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train, bus

    best
    1. Take the train from Poughkeepsie to 125th Street - Harlemtrain train Hudson
    2. Take the bus from New York, NY to Florence, SCbus bus Nyc
    16h 8m
    $119–183

  2. Train (Amtrak)

    1. Take the train from Poughkeepsie Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train Empire Service / ...
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Florence Stationtrain train Palmetto / ...
    17h 11m
    $224–468

  3. Drive 695.3 mi

    1. Drive from Poughkeepsie to Florence Stationcar car 695.3 mi
    12h 29m
    $127–184

  4. Train to Laguardia Airport, fly to Myrtle Beach, bus, train

    1. Take the train from Poughkeepsie to 125th Street - Harlemtrain train
    2. Fly from Laguardia Airport (LGA) to Myrtle Beach (MYR)plane plane LGA - MYR
    3. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    4. Take the train from Charleston Amtrak Station to Florence Stationtrain train
    11h 12m
    $147–544

  5. Bus

    1. Take the bus from Newburgh ShortLine Transportation Center to Port Authority Bus Terminalbus bus
    2. Take the bus from Port Authority Bus Terminal to Raleigh Bus Stationbus bus
    3. Take the bus from Raleigh Bus Station to Florence Bus Stationbus bus
    19h 2m
    $125–268

  6. Train to Newark Liberty International Airport, fly to Myrtle Beach, bus, train

    1. Take the train from Poughkeepsie Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Fly from Newark Liberty International Airport (EWR) to Myrtle Beach (MYR)plane plane EWR - MYR
    3. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    4. Take the train from Charleston Amtrak Station to Florence Stationtrain train
    11h 11m
    $450–934

  7. Train to Laguardia Airport, fly to Raleigh-Durham International Airport, train

    1. Take the train from Poughkeepsie to 125th Street - Harlemtrain train
    2. Fly from Laguardia Airport (LGA) to Raleigh-Durham International Airport (RDU)plane plane LGA - RDU
    3. Take the train from Raleigh Union Station to Selma Stationtrain train
    4. Take the train from Selma Station to Florence Stationtrain train
    12h 6m
    $243–588

  8. Train to Newark Liberty International Airport, fly to Raleigh-Durham International Airport, train

    1. Take the train from Poughkeepsie Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Fly from Newark Liberty International Airport (EWR) to Raleigh-Durham International Airport (RDU)plane plane EWR - RDU
    3. Take the train from Raleigh Union Station to Selma Stationtrain train
    4. Take the train from Selma Station to Florence Stationtrain train
    11h 57m
    $286–1,188

  9. Fly Stewart International Airport to Myrtle Beach, bus, train

    1. Fly from Stewart International Airport (SWF) to Myrtle Beach (MYR)plane plane SWF - MYR
    2. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    3. Take the train from Charleston Amtrak Station to Florence Stationtrain train
    11h
    $405–877

  10. Train to Westchester County Airport, fly to Charlotte Douglas International Airport, bus

    1. Take the train from Poughkeepsie to 125th Street - Harlemtrain train
    2. Fly from Westchester County Airport (HPN) to Charlotte Douglas International Airport (CLT)plane plane HPN - CLT
    3. Take the bus from Charlotte Bus Station to Camdenbus bus
    4. Take the bus from Camden to Florence Bus Stationbus bus
    12h 54m
    $192–889

  11. Train to Westchester County Airport, fly to Myrtle Beach, bus, train

    1. Take the train from Poughkeepsie to 125th Street - Harlemtrain train
    2. Fly from Westchester County Airport (HPN) to Myrtle Beach (MYR)plane plane HPN - MYR
    3. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    4. Take the train from Charleston Amtrak Station to Florence Stationtrain train
    13h 2m
    $265–1,253

  12. Train, train to Tweed-New Haven Airport, fly to Myrtle Beach, bus

    1. Take the train from Poughkeepsie to 125th Street - Harlemtrain train
    2. Take the train from 125th Street - Harlem to New Haventrain train
    3. Fly from Tweed-New Haven Airport (HVN) to Myrtle Beach (MYR)plane plane HVN - MYR
    4. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    5. Take the train from Charleston Amtrak Station to Florence Stationtrain train
    14h 17m
    $205–656

Poughkeepsie to Florence Station by train (Amtrak)

Calendar14Weekly Trains
Duration17h 11mAverage Duration
Ticket$224Cheapest Price
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Questions & Answers

Map of how to get from Poughkeepsie to Florence Station.ExpandLaunch map view
  • Distance: 758.6 mi
  • Duration: 16h 8m

What companies run services between Poughkeepsie, NY, USA and Florence Station, SC, USA?

You can take a train from Poughkeepsie Amtrak Station to Florence Station via Ny Moynihan Train Hall At Penn Station in around 17h 11m. Alternatively, you can take a train from Poughkeepsie to Florence Station via Beacon, Beacon Station, Newburgh ShortLine Transportation Center, Port Authority Bus Terminal, Raleigh Bus Station, and Florence Bus Station in around 19h 2m.

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