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How to get fromPoughkeepsie to Knoxvilleby train, plane, bus, or car

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There are 8 ways to get from Poughkeepsie to Knoxville by train, plane, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Newark Liberty International Airport, fly to Mcghee Tyson Airport

    best
    1. Take the train from Poughkeepsie Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Fly from Newark Liberty International Airport (EWR) to Mcghee Tyson Airport (TYS)plane plane EWR - TYS
    5h 29m
    $245–990

  2. Train to Laguardia Airport, fly to Asheville Regional Airport, drive

    cheapest
    1. Take the train from Poughkeepsie to 125th Street - Harlemtrain train
    2. Fly from Laguardia Airport (LGA) to Asheville Regional Airport (AVL)plane plane LGA - AVL
    3. Drive from Asheville-Airport-AVL to Knoxvillecar car
    7h 30m
    $128–561

  3. Train, bus

    1. Take the train from Poughkeepsie Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train Empire Service / ...
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    15h 7m
    $157–205

  4. Drive  744.5 mi

    1. Drive from Poughkeepsie to Knoxvillecar car 744.5 mi
    13h 16m
    $136–197

  5. Train to Laguardia Airport, fly to Mcghee Tyson Airport

    1. Take the train from Poughkeepsie to 125th Street - Harlemtrain train
    2. Fly from Laguardia Airport (LGA) to Mcghee Tyson Airport (TYS)plane plane LGA - TYS
    5h 43m
    $266–1,206

  6. Train, train to Philadelphia International Airport, fly to Mcghee Tyson Airport

    1. Take the train from Poughkeepsie Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Take the train from Ny Moynihan Train Hall At Penn Station to 30th Street Stationtrain train
    3. Fly from Philadelphia International Airport (PHL) to Mcghee Tyson Airport (TYS)plane plane PHL - TYS
    7h 2m
    $277–1,815

  7. Train to Newark Liberty International Airport, fly to Asheville Regional Airport, drive

    1. Take the train from Poughkeepsie Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Fly from Newark Liberty International Airport (EWR) to Asheville Regional Airport (AVL)plane plane EWR - AVL
    3. Drive from Asheville-Airport-AVL to Knoxvillecar car
    7h 19m
    $132–495

  8. Train, bus via Farragut

    1. Take the train from Poughkeepsie to Grand Central Terminaltrain train Hudson
    2. Take the bus from New York to Knoxvillebus bus Nyc
    15h 27m
    $202–282

Newark Liberty International Airport (EWR) to Mcghee Tyson Airport (TYS) flights

Calendar78Weekly Planes
Duration4h 1mAverage Duration
Ticket$155Cheapest Price
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Comparing Your Travel Options

Map of how to get from Poughkeepsie to Knoxville.ExpandLaunch map view
  • Distance: 729.4 mi
  • Duration: 5h 29m

What companies run services between Poughkeepsie, NY, USA and Knoxville, TN, USA?

There is no direct connection from Poughkeepsie to Knoxville. However, you can take the train to Ny Moynihan Train Hall At Penn Station, walk to Penn Station, take the train to Newark Airport Railroad Station, walk to Newark Airport Railroad Station, take the vehicle to Terminal B, walk to Newark Liberty International Airport (EWR) airport, fly to Mcghee Tyson Airport (TYS), then take the taxi to Knoxville. Alternatively, you can take a train from Poughkeepsie Amtrak Station to Knoxville via Ny Moynihan Train Hall At Penn Station, 34 St-Herald Sq, East Broadway, New York, NY, and Knoxville, TN in around 15h 7m.

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