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How to get fromPoughkeepsie to Louisvilleby train, plane, bus, or car

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There are 8 ways to get from Poughkeepsie to Louisville by train, plane, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Laguardia Airport, fly to Louisville International Airport

    best
    1. Take the train from Poughkeepsie to 125th Street - Harlemtrain train
    2. Fly from Laguardia Airport (LGA) to Louisville International Airport (SDF)plane plane LGA - SDF
    6h 52m
    $192–1,039

  2. Train to Laguardia Airport, fly to Blue Grass Airport, drive

    cheapest
    1. Take the train from Poughkeepsie to 125th Street - Harlemtrain train
    2. Fly from Laguardia Airport (LGA) to Blue Grass Airport (LEX)plane plane LGA - LEX
    3. Drive from Lexington-Airport-LEX to Louisvillecar car
    6h 41m
    $124–605

  3. Train, bus via Toledo

    1. Take the train from Poughkeepsie Amtrak Station to Toledotrain train
    2. Take the bus from Toledo to Indianapolisbus bus
    3. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    21h 3m
    $402–660

  4. Train, bus

    1. Take the train from Poughkeepsie to Grand Central Terminaltrain train
    2. Take the bus from Port Authority Bus Terminal to Indianapolis Union Stationbus bus
    3. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    23h 7m
    $184–302

  5. Drive  774.5 mi

    1. Drive from Poughkeepsie to Louisvillecar car 774.5 mi
    13h 49m
    $142–205

  6. Train to Newark Liberty International Airport, fly to Louisville International Airport

    1. Take the train from Poughkeepsie Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Fly from Newark Liberty International Airport (EWR) to Louisville International Airport (SDF)plane plane EWR - SDF
    6h 44m
    $193–893

  7. Train, train to Philadelphia International Airport, fly to Louisville International Airport

    1. Take the train from Poughkeepsie Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Take the train from Ny Moynihan Train Hall At Penn Station to 30th Street Stationtrain train
    3. Fly from Philadelphia International Airport (PHL) to Louisville International Airport (SDF)plane plane PHL - SDF
    8h 4m
    $223–1,618

  8. Train, bus #2 (Amtrak)

    1. Take the train from Poughkeepsie Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Indianapolistrain train
    3. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    28h 40m
    $562–906

Poughkeepsie to Louisville by train and bus

Calendar7Weekly Services
Duration21h 3mAverage Duration
Ticket$402Cheapest Price
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Comparing Your Travel Options

Map of how to get from Poughkeepsie to Louisville.ExpandLaunch map view
  • Distance: 739.3 mi
  • Duration: 6h 52m

What companies run services between Poughkeepsie, NY, USA and Louisville, KY, USA?

There is no direct connection from Poughkeepsie to Louisville. However, you can take the train to 125th Street - Harlem, walk to E 125 St/Lexington Av, take the bus to Laguardia Rd/94 St, walk to New-York-La-Guardia-Airport-LGA airport, fly to Louisville International Airport (SDF), walk to Louisville International Airport, then take the line 02 bus to 2nd @ York. Alternatively, you can take a train from Poughkeepsie Amtrak Station to Louisville, KY via Toledo, Toledo, and Indianapolis Union Station in around 21h 3m.

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