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How to get fromPoughkeepsie to Winston-Salemby train, plane, bus, or car

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There are 9 ways to get from Poughkeepsie to Winston-Salem by train, plane, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Laguardia Airport, fly to Piedmont Triad International Airport

    best
    1. Take the train from Poughkeepsie to 125th Street - Harlemtrain train
    2. Fly from Laguardia Airport (LGA) to Piedmont Triad International Airport (GSO)plane plane LGA - GSO
    6h 9m
    $160–809

  2. Bus

    cheapest
    1. Take the bus from Newburgh ShortLine Transportation Center to Broadway & Chambers Stbus bus ShortLine Hudson
    2. Take the bus from New York, NY to Winston-Salem, NCbus bus Nyc
    15h 36m
    $108–171

  3. Train, bus via Greensboro

    1. Take the train from Poughkeepsie Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Greensborotrain train
    3. Take the bus from Greensboro Bus Stop to Winston Salem(Trans Center)bus bus
    14h 25m
    $163–362

  4. Drive 598.9 mi

    1. Drive from Poughkeepsie to Winston-Salemcar car 598.9 mi
    11h 34m
    $110–158

  5. Train to Newark Liberty International Airport, fly to Piedmont Triad International Airport

    1. Take the train from Poughkeepsie Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Fly from Newark Liberty International Airport (EWR) to Piedmont Triad International Airport (GSO)plane plane EWR - GSO
    6h 5m
    $160–695

  6. Train to Laguardia Airport, fly to Charlotte Douglas International Airport, bus

    1. Take the train from Poughkeepsie to 125th Street - Harlemtrain train
    2. Fly from Laguardia Airport (LGA) to Charlotte Douglas International Airport (CLT)plane plane LGA - CLT
    3. Take the bus from Charlotte Bus Station to Winston Salem(Trans Center)bus bus
    8h 21m
    $162–682

  7. Train to Laguardia Airport, fly to Raleigh-Durham International Airport, bus

    1. Take the train from Poughkeepsie to 125th Street - Harlemtrain train
    2. Fly from Laguardia Airport (LGA) to Raleigh-Durham International Airport (RDU)plane plane LGA - RDU
    3. Take the bus from Durham to Winston Salem(Trans Center)bus bus
    9h 2m
    $158–504

  8. Train to Newark Liberty International Airport, fly to Raleigh-Durham International Airport, bus

    1. Take the train from Poughkeepsie Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Fly from Newark Liberty International Airport (EWR) to Raleigh-Durham International Airport (RDU)plane plane EWR - RDU
    3. Take the bus from Durham to Winston Salem(Trans Center)bus bus
    8h 55m
    $208–1,000

  9. Train, bus

    1. Take the train from Poughkeepsie to Grand Central Terminaltrain train Hudson
    2. Take the bus from Port Authority Bus Terminal to Winston Salem(Trans Center)bus bus Greyhound US0670
    18h 17m
    $112–207

Poughkeepsie to Winston-Salem by train and bus

Calendar14Weekly Services
Duration14h 25mAverage Duration
Ticket$163Cheapest Price
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Questions & Answers

Map of how to get from Poughkeepsie to Winston-Salem.ExpandLaunch map view
  • Distance: 559.1 mi
  • Duration: 6h 9m

What companies run services between Poughkeepsie, NY, USA and Winston-Salem, NC, USA?

You can take a train from Poughkeepsie to Winston-Salem, NC via Beacon, Beacon Station, Newburgh ShortLine Transportation Center, Broadway & Chambers St, Frankfort St/William St, Madison St/Pike St, and New York, NY in around 15h 36m.

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