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How to get fromPoughkeepsie to Winston-Salemby train, plane, train (Amtrak), bus, or car

Find Transport to Winston-Salem

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There are 8 ways to get from Poughkeepsie to Winston-Salem by train, plane, train (Amtrak), bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Laguardia Airport, fly to Piedmont Triad International Airport

    best
    1. Take the train from Poughkeepsie to 125th Street - Harlemtrain train
    2. Fly from Laguardia Airport (LGA) to Piedmont Triad International Airport (GSO)plane plane LGA - GSO
    6h 6m
    $120–549

  2. Bus

    cheapest
    1. Take the bus from Newburgh ShortLine Transportation Center to Broadway & Murray Stbus bus ShortLine Hudson
    2. Take the bus from New York, NY to Winston-Salem, NCbus bus Nyc
    15h 28m
    $108–171

  3. Train (Amtrak)

    1. Take the train from Poughkeepsie Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train Empire Service / ...
    2. Take the train from Ny Moynihan Train Hall At Penn Station to High Pointtrain train Crescent / ...
    15h 2m
    $323–517

  4. Drive  598.9 mi

    1. Drive from Poughkeepsie to Winston-Salemcar car 598.9 mi
    11h 34m
    $110–158

  5. Train to Newark Liberty International Airport, fly to Piedmont Triad International Airport

    1. Take the train from Poughkeepsie Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Fly from Newark Liberty International Airport (EWR) to Piedmont Triad International Airport (GSO)plane plane EWR - GSO
    6h 19m
    $141–493

  6. Train to Laguardia Airport, fly to Charlotte Douglas International Airport, bus

    1. Take the train from Poughkeepsie to 125th Street - Harlemtrain train
    2. Fly from Laguardia Airport (LGA) to Charlotte Douglas International Airport (CLT)plane plane LGA - CLT
    3. Take the bus from Charlotte Bus Station to Winston Salem(Trans Center)bus bus
    8h 23m
    $168–663

  7. Train to Laguardia Airport, fly to Raleigh-Durham International Airport, bus

    1. Take the train from Poughkeepsie to 125th Street - Harlemtrain train
    2. Fly from Laguardia Airport (LGA) to Raleigh-Durham International Airport (RDU)plane plane LGA - RDU
    3. Take the bus from Durham to Winston Salem(Trans Center)bus bus
    9h 15m
    $161–503

  8. Train, bus

    1. Take the train from Poughkeepsie to Grand Central Terminaltrain train Hudson
    2. Take the bus from Port Authority Bus Terminal to Winston Salem(Trans Center)bus bus Greyhound US0670
    18h 22m
    $132–207

Poughkeepsie to Winston-Salem by train and bus (Amtrak)

Calendar14Weekly Services
Duration15h 2mAverage Duration
Ticket$323Cheapest Price
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Comparing Your Travel Options

Map of how to get from Poughkeepsie to Winston-Salem.ExpandLaunch map view
  • Distance: 559.1 mi
  • Duration: 6h 6m

What companies run services between Poughkeepsie, NY, USA and Winston-Salem, NC, USA?

You can take a train from Poughkeepsie Amtrak Station to Winston-Salem Transportation Center via Ny Moynihan Train Hall At Penn Station, High Point, and High Point Terminal in around 15h 2m. Alternatively, you can take a train from Poughkeepsie to Winston-Salem, NC via Beacon, Beacon Station, Newburgh ShortLine Transportation Center, Broadway & Murray St, Warren St/Church St, and New York, NY in around 15h 28m.

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