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How to get fromPrague to Mainzby subway, plane, train, bus, or car

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There are 8 ways to get from Prague to Mainz by subway, plane, train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Subway to Václav Havel Airport Prague, fly

    best
    1. Take the subway from Staroměstská to Nádraží Veleslavínsubway subway
    2. Fly from Václav Havel Airport Prague (PRG) to Frankfurt (FRA)plane plane PRG - FRA
    4h 6m
    €61–135

  2. Bus

    cheapest
    1. Take the bus from Praha, Hlavní Nádraží to Mainz central train stationbus bus N1310
    8h 35m
    €45–75

  3. Train via Erfurt

    1. Take the train from Praha-Holesovice to Dresden Hbftrain train Rj
    2. Take the train from Dresden Hauptbahnhof to Leipzig Hbftrain train 55 / ...
    3. Take the train from Leipzig Hbf to Erfurt Hbftrain train 28 / ...
    4. Take the train from Erfurt Hbf to Frankfurttrain train 12 / ...
    8h 3m
    €102–317

  4. Drive  539.5 km

    1. Drive from Prague to Mainzcar car 539.5 km
    4h 28m
    €86–124

  5. Train to Dresden Airport, fly

    1. Take the train from Praha-Holesovice to Dresden Hbftrain train
    2. Fly from Dresden Airport (DRS) to Frankfurt (FRA)plane plane DRS - FRA
    5h 26m
    €141–371

  6. Bus to Nuremberg Airport, fly

    1. Take the bus from Prague to Nuremberg central bus stationbus bus
    2. Fly from Nuremberg Airport (NUE) to Frankfurt (FRA)plane plane NUE - FRA
    5h 56m
    €126–222

  7. Train

    1. Take the train from Praha Hlavní nádraží to Frankfurttrain train Drf
    9h 55m

  8. Bus via Frankfurt am Main

    1. Take the bus from Praha Hlavní nádraží to Frankfurt, Hauptbahnhof FOBbus bus Ivano-Frankivsk
    17h 49m
    €130–161

Prague to Mainz by train

Calendar94Weekly Trains
Duration8h 3mAverage Duration
Ticket€102Cheapest Price
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Comparing Your Travel Options

Map of how to get from Prague to Mainz.ExpandLaunch map view
  • Distance: 446.7 km
  • Duration: 4h 6m

What companies run services between Prague, Czechia and Mainz, Germany?

You can take a train from Praha-Holesovice to Mainz, Römisches Theater via Dresden Hauptbahnhof, Leipzig Hbf, Erfurt Hbf, and Frankfurt in around 8h 3m. Alternatively, FlixBus operates a bus from Praha, Hlavní Nádraží to Mainz central train station once daily. Tickets cost €45–75 and the journey takes 8h 35m.

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